Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 4/20 | 0.45 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.45 |
| ▸ | TNIK | Q9UKE5 | 10/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13333228 | 0.77 | TNIK (0.46) | TBK1IKBKETNIKMAPTTP53 | |
| SCHEMBL13333375 | 0.77 | TNIK (0.47) | TNIKMAPTTP53 | |
| SCHEMBL3394633 | 0.76 | TBK1 (0.77) | TBK1IKBKETNIK | |
| SCHEMBL13333379 | 0.75 | TNIK (0.58) | TBK1IKBKETNIKMAPTPIP5K1C | |
| SCHEMBL3393610 | 0.70 | TNIK (0.74) | TBK1IKBKETNIKMAPTTP53 | |
| SCHEMBL3396744 | 0.70 | TBK1 (0.69) | TBK1IKBKETNIKMAPTTP53 | |
| SCHEMBL3390831 | 0.69 | TNIK (0.64) | TBK1IKBKETNIKMAPTTP53 | |
| SCHEMBL15713027 | 0.69 | TNIK (0.55) | TNIKMAPTTP53LMNAPOLB | |
| SCHEMBL13333407 | 0.68 | MAPT (0.56) | TNIKMAPTTP53LMNAPOLB | |
| SCHEMBL13333383 | 0.68 | TNIK (0.43) | TNIKMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010064111-A1 | TNIK INHIBITOR AND THE USE | YAMADA TESSHI (JP) | 2010-06-10 | — | — | WO | disclosed |