Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1332949 | 0.93 | MAPT (0.41) | MAPTKMT2AMAPK1L3MBTL1SMN1; SMN2 | |
| SCHEMBL28331905 | 0.91 | MAPT (0.40) | MAPTKMT2AMAPK1L3MBTL1SMN1; SMN2 | |
| SCHEMBL1333743 | 0.82 | F10 (0.38) | MAPTKMT2AMAPK1L3MBTL1SMN1; SMN2 | |
| SCHEMBL7473370 | 0.76 | MAPT (0.41) | MAPTKMT2AL3MBTL1SMN1; SMN2POLB | |
| SCHEMBL7784131 | 0.76 | MAPT (0.39) | MAPTKMT2AMAPK1L3MBTL1SMN1; SMN2 | |
| SCHEMBL5550214 | 0.75 | KMT2A (0.47) | MAPTKMT2AMAPK1L3MBTL1SMN1; SMN2 | |
| SCHEMBL28356124 | 0.75 | MAPT (0.44) | MAPTKMT2AMAPK1L3MBTL1SMN1; SMN2 | |
| SCHEMBL10026219 | 0.74 | TSHR (0.36) | MAPTKMT2AMAPK1L3MBTL1SMN1; SMN2 | |
| SCHEMBL5551024 | 0.74 | KMT2A (0.42) | MAPTKMT2AMAPK1L3MBTL1SMN1; SMN2 | |
| SCHEMBL5549293 | 0.74 | MAPT (0.39) | MAPTKMT2AMAPK1L3MBTL1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 71 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3367143-B1 | POLARIZING PHOTOCHROMIC DEVICES AND METHODS OF MAKING THE SAME | TRANSITIONS OPTICAL INC (US) | 2023-01-11 | — | — | EP | claimed |
| EP-1639058-B1 | PHOTOCHROMIC COMPOUNDS | TRANSITIONS OPTICAL INC (US) | 2020-10-21 | — | — | EP | claimed |
| EP-3367143-A1 | POLARIZING PHOTOCHROMIC DEVICES AND METHODS OF MAKING THE SAME | Transitions Optical, Inc. (US) | 2018-08-29 | — | — | EP | claimed |
| US-7847998-B2 | Polarizing, photochromic devices and methods of making the same | TRANSITIONS OPTICAL, INC. (US) | 2010-12-07 | — | — | US | claimed |
| US-7505189-B2 | Polarizing, photochromic devices and methods of making the same | TRANSITIONS OPTICAL, INC. (US) | 2009-03-17 | — | — | US | claimed |
| CN-100416314-C | Polarizing, photochromic devices and methods of making the same | TRANSITIONS OPTICAL INC (US) | 2008-09-03 | — | — | CN | claimed |
| US-20070098968-A1 | Polarizing, photochromic devices and methods of making the same | TRANSITIONS OPTICAL LIMITED (IE) | 2007-05-03 | — | — | US | claimed |
| US-20070075388-A1 | Polarizing, photochromic devices and methods of making the same | TRANSITIONS OPTICAL LIMITED (IE) | 2007-04-05 | — | — | US | claimed |
| CN-1842730-A | Polarizing, photochromic devices and methods of making the same | TRANSITIONS OPTICAL INC (US) | 2006-10-04 | — | — | CN | claimed |
| EP-1642160-A1 | POLARIZING PHOTOCHROMIC DEVICES AND METHODS OF MAKING THE SAME | TRANSITIONS OPTICAL, INC. (US) | 2006-04-05 | — | — | EP | claimed |
| EP-1639058-A1 | PHOTOCHROMIC COMPOUNDS | TRANSITIONS OPTICAL, INC. (US) | 2006-03-29 | — | — | EP | claimed |
| WO-2005005570-A1 | PHOTOCHROMIC COMPOUNDS | TRANSITIONS OPTICAL, INC. (US) | 2005-01-20 | — | — | WO | claimed |
| WO-2005006035-A1 | POLARIZING PHOTOCHROMIC DEVICES AND METHODS OF MAKING THE SAME | TRANSITIONS OPTICAL, INC. (US) | 2005-01-20 | — | — | WO | claimed |
| US-20050012998-A1 | Polarizing, photochromic devices and methods of making the same | TRANSITIONS OPTICAL LIMITED (IE) | 2005-01-20 | — | — | US | claimed |
| US-20050004361-A1 | Thermally reversible; absorption ratio greater than 2.3 | TRANSITIONS OPTICAL LIMITED (IE) | 2005-01-06 | — | — | US | claimed |
| EP-2718755-B1 | POLARIZING PHOTOCHROMIC ARTICLES | TRANSITIONS OPTICAL INC (US) | 2024-05-29 | — | — | EP | disclosed |
| EP-3367143-B1 | POLARIZING PHOTOCHROMIC DEVICES AND METHODS OF MAKING THE SAME | TRANSITIONS OPTICAL INC (US) | 2023-01-11 | — | — | EP | disclosed |
| WO-2005005570-A1 | PHOTOCHROMIC COMPOUNDS | TRANSITIONS OPTICAL, INC. (US) | 2005-01-20 | — | — | WO | disclosed |
| WO-2005006035-A1 | POLARIZING PHOTOCHROMIC DEVICES AND METHODS OF MAKING THE SAME | TRANSITIONS OPTICAL, INC. (US) | 2005-01-20 | — | — | WO | disclosed |
| US-20050004361-A1 | Thermally reversible; absorption ratio greater than 2.3 | TRANSITIONS OPTICAL LIMITED (IE) | 2005-01-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050004361-A1 | Thermally reversible; absorption ratio greater than 2.3 | CCND1, CCND3, CCND2 | MAPT 4150/4885KMT2A 1838/4885MAPK1 4643/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.