Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NMT2 | O60551 | 4/20 | 0.48 |
| ▸ | NMT1 | P30419 | 4/20 | 0.48 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | CDK1 | P06493 | 1/20 | 0.45 |
| ▸ | CDK4 | P11802 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | AKT1 | P31749 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 2/20 | 0.43 |
| ▸ | ACHE | P22303 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13349883 | 0.86 | ALDH1A1 (0.43) | KDM4EHTTHPGDKCNH2ACHE | |
| SCHEMBL13106408 | 0.85 | PLA2G2A (0.50) | NMT2NMT1PLA2G2AKDM4EAURKA | |
| SCHEMBL13106419 | 0.84 | PLA2G2A (0.44) | NMT2NMT1PLA2G2AKDM4EAURKA | |
| SCHEMBL13096569 | 0.81 | SMN1; SMN2 (0.52) | PLA2G2AKDM4EHTTHPGDMAPT | |
| SCHEMBL13349767 | 0.79 | CTSL (0.47) | PLA2G2AKDM4EHPGDSLC2A1MAPT | |
| SCHEMBL15493306 | 0.77 | PLA2G2A (0.46) | NMT2NMT1PLA2G2ASLC2A1BCHE | |
| SCHEMBL2553820 | 0.75 | DYRK3 (0.62) | PLA2G2AKDM4EAURKACDK1CDK4 | |
| SCHEMBL12858402 | 0.75 | KDM4E (0.51) | PLA2G2AKDM4EHTTAURKACDK1 | |
| SCHEMBL12627543 | 0.74 | AHR (0.46) | PLA2G2AKDM4EHTTMAPTTSHR | |
| SCHEMBL14884628 | 0.73 | HASPIN (0.55) | KDM4EAURKACDK1CDK4CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8367702-B2 | Quinolone derivative | ASTELLAS PHARMA INC. (JP) | 2013-02-05 | — | — | US | disclosed |
| EP-2194044-A1 | QUINOLONE DERIVATIVE | Astellas Pharma Inc. (JP) | 2010-06-09 | — | — | EP | disclosed |