Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13349766 | 0.86 | NMT2 (0.48) | ALDH1A1KDM4ENPC1GAARAB9A | |
| SCHEMBL13107161 | 0.83 | RAB9A (0.39) | ALDH1A1KDM4ENPC1GAARAB9A | |
| SCHEMBL13107201 | 0.83 | KCNH2 (0.39) | ALDH1A1KDM4ENPC1GAARAB9A | |
| SCHEMBL13349805 | 0.80 | LMNA (0.37) | ALDH1A1KDM4ENPC1GAARAB9A | |
| SCHEMBL3103639 | 0.78 | L3MBTL1 (0.50) | KDM4ELMNAHTTSMN1; SMN2MAPT | |
| SCHEMBL2124437 | 0.78 | KDM4E (0.46) | ALDH1A1KDM4ELMNAHTTSMN1; SMN2 | |
| SCHEMBL13106409 | 0.78 | ALDH1A1 (0.40) | ALDH1A1KDM4EGAAHTTMAPT | |
| SCHEMBL14452725 | 0.72 | CHRM4 (0.44) | ALDH1A1KDM4ENPC1GAARAB9A | |
| SCHEMBL13106408 | 0.71 | PLA2G2A (0.50) | ALDH1A1KDM4EKCNH2ACHEHPGD | |
| SCHEMBL13107207 | 0.71 | POLB (0.43) | KDM4EGAAMEN1TSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8367702-B2 | Quinolone derivative | ASTELLAS PHARMA INC. (JP) | 2013-02-05 | — | — | US | disclosed |
| EP-2194044-A1 | QUINOLONE DERIVATIVE | Astellas Pharma Inc. (JP) | 2010-06-09 | — | — | EP | disclosed |