Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 6/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.47 |
| ▸ | PRKACA | P17612 | 4/20 | 0.47 |
| ▸ | PRKX | P51817 | 4/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.47 |
| ▸ | PRKG1 | Q13976 | 3/20 | 0.47 |
| ▸ | GSK3B | P49841 | 3/20 | 0.47 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.47 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.47 |
| ▸ | GSK3A | P49840 | 2/20 | 0.47 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.47 |
| ▸ | RPS6KA4 | O75676 | 2/20 | 0.47 |
| ▸ | SGK2 | Q9HBY8 | 1/20 | 0.47 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.42 |
| ▸ | PRKG2 | Q13237 | 1/20 | 0.42 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1335713 | 0.98 | ROCK1 (0.46) | ROCK1ROCK2PRKACAPRKXCLK4 | |
| SCHEMBL6192681 | 0.87 | ROCK2 (0.59) | ROCK1ROCK2PRKACAPRKXCLK4 | |
| SCHEMBL16009906 | 0.85 | CYP3A4 (0.51) | ROCK1ROCK2PRKACAPRKXCLK4 | |
| SCHEMBL3461327 | 0.81 | ACACB (0.41) | MAPK1CYP3A4MME | |
| SCHEMBL1520114 | 0.81 | MME (0.48) | ROCK1ROCK2PRKACAPRKXCLK4 | |
| SCHEMBL5469880 | 0.80 | FFAR2 (0.46) | MMEFFAR2 | |
| SCHEMBL1519730 | 0.80 | FFAR2 (0.46) | MMEFFAR2 | |
| SCHEMBL21144973 | 0.77 | MMP12 (0.42) | MME | |
| SCHEMBL21144971 | 0.77 | MMP12 (0.42) | MME | |
| SCHEMBL3222270 | 0.76 | GSK3B (0.44) | ROCK1ROCK2PRKACAPRKXCLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110275678-A1 | New Pyridine Derivatives as Leptin Receptor Modulator Mimetics | BIOVITRUM AB (SE) | 2011-11-10 | — | — | US | claimed |
| EP-2313094-A1 | NEW PYRIDINE DERIVATIVES AS LEPTIN RECEPTOR MODULATOR MIMETICS | AstraZeneca AB (SE) | 2011-04-27 | — | — | EP | claimed |
| US-20110275678-A1 | New Pyridine Derivatives as Leptin Receptor Modulator Mimetics | BIOVITRUM AB (SE) | 2011-11-10 | — | — | US | disclosed |
| EP-2313094-A1 | NEW PYRIDINE DERIVATIVES AS LEPTIN RECEPTOR MODULATOR MIMETICS | AstraZeneca AB (SE) | 2011-04-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110275678-A1 | New Pyridine Derivatives as Leptin Receptor Modulator Mimetics | GPR119, GLP1R, ADIPOR1 | ROCK1 3450/4885ROCK2 3100/4885PRKACA 3901/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.