Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.57 |
| ▸ | MEN1 | O00255 | 5/20 | 0.57 |
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 4/20 | 0.54 |
| ▸ | RAB9A | P51151 | 4/20 | 0.54 |
| ▸ | MAPT | P10636 | 9/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.53 |
| ▸ | RELA | Q04206 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | SORD | Q00796 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1432869 | 0.80 | MAPT (0.51) | MAPTALDH1A1SMN1; SMN2LMNANPSR1 | |
| SCHEMBL13102362 | 0.79 | KMT2A (0.57) | KMT2AMEN1ATMNPC1RAB9A | |
| SCHEMBL29377667 | 0.79 | KMT2A (0.57) | KMT2AMEN1ATMNPC1RAB9A | |
| SCHEMBL2395006 | 0.79 | KMT2A (0.57) | KMT2AMEN1ATMNPC1RAB9A | |
| SCHEMBL29356115 | 0.79 | ALDH1A1 (0.55) | KMT2AMEN1MAPTALDH1A1GAA | |
| SCHEMBL1928408 | 0.79 | ALDH1A1 (0.55) | KMT2AMEN1MAPTALDH1A1GAA | |
| SCHEMBL4517601 | 0.79 | HTR3A (0.51) | KMT2ARAB9AALDH1A1KDM4E | |
| SCHEMBL1432610 | 0.78 | MAPT (0.53) | MAPTALDH1A1HPGDSMN1; SMN2LMNA | |
| SCHEMBL3832779 | 0.77 | ME2 (0.47) | KMT2AMEN1NPC1RAB9AMAPT | |
| SCHEMBL6590995 | 0.76 | KMT2A (0.72) | KMT2AMEN1ATMNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059602-A2 | INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE | SCHERING CORPORATION (US) | 2010-05-27 | — | — | WO | disclosed |