Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 6/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 6/20 | 0.34 |
| ▸ | SMO | Q99835 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13356741 | 0.88 | CYP19A1 (0.42) | SLC6A2SLC6A4SLC6A3CYP1A2CYP3A4 | |
| SCHEMBL708822 | 0.83 | PDE7A (0.36) | CYP19A1ALDH1A1SMN1; SMN2SMOTDP1 | |
| SCHEMBL13356827 | 0.81 | SLC6A2 (0.39) | SLC6A2SLC6A4SLC6A3CYP1A2CYP3A4 | |
| SCHEMBL13356967 | 0.81 | SLC6A2 (0.45) | SLC6A2SLC6A4SLC6A3ALDH1A1CYP11B1 | |
| SCHEMBL3254071 | 0.74 | APP (0.40) | ALDH1A1SMN1; SMN2TDP1KDM4EPOLB | |
| SCHEMBL3254604 | 0.72 | MAPT (0.39) | CYP19A1ALDH1A1SMN1; SMN2CYP11B1CYP11B2 | |
| SCHEMBL3256198 | 0.72 | MAPT (0.37) | CYP19A1ALDH1A1KDM4ELMNAMEN1 | |
| SCHEMBL3253737 | 0.69 | L3MBTL1 (0.41) | CYP19A1ALDH1A1SMN1; SMN2TDP1KDM4E | |
| SCHEMBL711641 | 0.68 | MAPT (0.38) | ALDH1A1SMN1; SMN2KDM4ELMNAHTT | |
| SCHEMBL710094 | 0.68 | PDE7A (0.36) | ALDH1A1SMN1; SMN2TDP1KDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1585727-B1 | INDOLES USEFUL IN THE TREATMENT OF ANDROGEN-RECEPTOR RELATED DISEASES | ORGANON NV (NL) | 2010-05-26 | — | — | EP | disclosed |