Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | PKM | P14618 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.32 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.32 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | PDE5A | O76074 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | QPCT | Q16769 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL710542 | 0.86 | ALDH1A1 (0.44) | MAPTPKMLMNAKDM4EALDH1A1 | |
| SCHEMBL708822 | 0.86 | PDE7A (0.36) | MAPTPKMLMNAKDM4EALDH1A1 | |
| SCHEMBL709751 | 0.86 | MAPT (0.47) | MAPTPKMLMNAKDM4EALDH1A1 | |
| SCHEMBL708494 | 0.86 | CNR1 (0.37) | LMNAALDH1A1RAB9AMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL710238 | 0.86 | MAPT (0.46) | MAPTPKMLMNAKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL709675 | 0.86 | ALDH1A1 (0.43) | MAPTPKMLMNAKDM4EALDH1A1 | |
| SCHEMBL3248070 | 0.82 | RAB9A (0.36) | MAPTPKMKDM4EALDH1A1GLA | |
| SCHEMBL711641 | 0.82 | MAPT (0.38) | MAPTPKMLMNAKDM4EALDH1A1 | |
| SCHEMBL3258185 | 0.82 | RAB9A (0.37) | MAPTPKMKDM4EALDH1A1GLA | |
| SCHEMBL3254071 | 0.80 | APP (0.40) | MAPTKDM4EALDH1A1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1585727-B1 | INDOLES USEFUL IN THE TREATMENT OF ANDROGEN-RECEPTOR RELATED DISEASES | ORGANON NV (NL) | 2010-05-26 | — | — | EP | claimed |