Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 2/20 | 0.64 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.56 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | NAMPT | P43490 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.50 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13359266 | 0.84 | MAPK14 (0.59) | MAPK14TMIGD3ADORA1HTTHPGD | |
| SCHEMBL13797975 | 0.83 | MAPK14 (0.55) | MAPK14HTTTSHRKDM4EALDH1A1 | |
| SCHEMBL13359167 | 0.82 | MAPK14 (0.54) | MAPK14HTTTSHRKDM4EALDH1A1 | |
| SCHEMBL13798013 | 0.79 | ALDH1A1 (0.54) | MAPK14HTTTSHRKDM4EALDH1A1 | |
| SCHEMBL13359285 | 0.78 | MAPK14 (1.00) | MAPK14TMIGD3ADORA1NAMPTHDAC1 | |
| SCHEMBL12368183 | 0.78 | MEN1 (0.64) | MAPK14HTTTSHRKDM4EALDH1A1 | |
| SCHEMBL903579 | 0.76 | MAPK14 (0.62) | MAPK14HTTTSHRKDM4EALDH1A1 | |
| SCHEMBL13359226 | 0.75 | MAPK1 (0.55) | MAPK14HTTTSHRKDM4EALDH1A1 | |
| SCHEMBL21446755 | 0.74 | TSHR (0.60) | MAPK14TMIGD3ADORA1TSHRKDM4E | |
| SCHEMBL13947606 | 0.74 | HTT (0.61) | MAPK14HTTTSHRKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1497278-B1 | HETEROCYCLIC AMIDE DERIVATIVES AS CYTOKINE INHIBITORS | BOEHRINGER INGELHEIM PHARMA (US) | 2010-05-26 | — | — | EP | disclosed |
| US-7550461-B2 | Benzofuran and benzothiophene compounds useful in treating cytokine mediated diseases | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2009-06-23 | — | — | US | disclosed |
| US-7550461-B2 | Benzofuran and benzothiophene compounds useful in treating cytokine mediated diseases | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2009-06-23 | — | — | US | disclosed |