Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13359167 | 0.88 | MAPK14 (0.54) | MAPK14ALDH1A1MAPTHTTKDM4E | |
| SCHEMBL13797972 | 0.88 | DHPS (0.47) | MAPK14ALDH1A1MAPTHTTKDM4E | |
| SCHEMBL13359147 | 0.83 | MAPK14 (0.64) | MAPK14ALDH1A1MAPTHTTKDM4E | |
| SCHEMBL13798013 | 0.82 | ALDH1A1 (0.54) | MAPK14ALDH1A1MAPTHTTKDM4E | |
| SCHEMBL13359226 | 0.81 | MAPK1 (0.55) | MAPK14ALDH1A1MAPTHTTKDM4E | |
| SCHEMBL13359290 | 0.80 | DHPS (0.44) | MAPK14ALDH1A1MAPTHTTKDM4E | |
| SCHEMBL13797993 | 0.80 | MAPK14 (0.74) | MAPK14 | |
| SCHEMBL13359142 | 0.78 | MAPT (0.48) | MAPK14ALDH1A1MAPTHTTKDM4E | |
| SCHEMBL13797974 | 0.76 | LYN (0.74) | MAPK14ALDH1A1MAPTHTTKDM4E | |
| SCHEMBL13811161 | 0.76 | DHPS (0.43) | MAPK14MAPTHTTKDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7550461-B2 | Benzofuran and benzothiophene compounds useful in treating cytokine mediated diseases | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2009-06-23 | — | — | US | disclosed |