Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.59 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.54 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.54 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.54 |
| ▸ | DHPS | P49366 | 2/20 | 0.53 |
| ▸ | TMIGD3 | P0DMS9 | 4/20 | 0.50 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.50 |
| ▸ | STAT1 | P42224 | 1/20 | 0.50 |
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.50 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.50 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13359147 | 0.84 | MAPK14 (0.64) | MAPK14HDAC2HDAC1HDAC3HDAC4 | |
| SCHEMBL13797972 | 0.84 | DHPS (0.47) | MAPK14HDAC2HDAC1HDAC3HDAC4 | |
| SCHEMBL13359290 | 0.81 | DHPS (0.44) | MAPK14HDAC2HDAC1HDAC3HDAC4 | |
| SCHEMBL13811161 | 0.79 | DHPS (0.43) | MAPK14HDAC2HDAC1HDAC3HDAC4 | |
| SCHEMBL13359291 | 0.78 | SMN1; SMN2 (0.51) | DHPSCASP3SENP8SENP7SENP6 | |
| SCHEMBL20436796 | 0.76 | PPARG (0.63) | PPARGHPGDHTTRAB9A | |
| SCHEMBL25422408 | 0.76 | HDAC2 (0.55) | MAPK14HDAC2HDAC1HDAC3HDAC4 | |
| SCHEMBL30464306 | 0.76 | HDAC2 (0.55) | MAPK14HDAC2HDAC1HDAC3HDAC4 | |
| SCHEMBL13359285 | 0.74 | MAPK14 (1.00) | MAPK14HDAC2HDAC1HDAC3HDAC4 | |
| SCHEMBL13359225 | 0.74 | HTT (0.52) | HPGDHTTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1497278-B1 | HETEROCYCLIC AMIDE DERIVATIVES AS CYTOKINE INHIBITORS | BOEHRINGER INGELHEIM PHARMA (US) | 2010-05-26 | — | — | EP | disclosed |
| US-7550461-B2 | Benzofuran and benzothiophene compounds useful in treating cytokine mediated diseases | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2009-06-23 | — | — | US | disclosed |
| US-7550461-B2 | Benzofuran and benzothiophene compounds useful in treating cytokine mediated diseases | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2009-06-23 | — | — | US | disclosed |