Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 2/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.54 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.54 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13797975 | 0.88 | MAPK14 (0.55) | MAPK14POLBALDH1A1MAPTHPGD | |
| SCHEMBL13359147 | 0.82 | MAPK14 (0.64) | MAPK14HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL13798013 | 0.81 | ALDH1A1 (0.54) | MAPK14HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL13359122 | 0.80 | MAPK14 (0.73) | MAPK14HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL13359226 | 0.80 | MAPK1 (0.55) | MAPK14POLBALDH1A1MAPTHPGD | |
| SCHEMBL13359142 | 0.77 | MAPT (0.48) | MAPK14POLBALDH1A1MAPTHPGD | |
| SCHEMBL13797974 | 0.75 | LYN (0.74) | MAPK14POLBALDH1A1MAPTHPGD | |
| SCHEMBL13797972 | 0.75 | DHPS (0.47) | MAPK14HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL2897562 | 0.75 | HDAC3 (0.68) | MAPK14HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL13359290 | 0.75 | DHPS (0.44) | MAPK14HDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1497278-B1 | HETEROCYCLIC AMIDE DERIVATIVES AS CYTOKINE INHIBITORS | BOEHRINGER INGELHEIM PHARMA (US) | 2010-05-26 | — | — | EP | disclosed |