Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.57 |
| ▸ | STAT3 | P40763 | 1/20 | 0.56 |
| ▸ | HPGDS | O60760 | 1/20 | 0.56 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.55 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.55 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.52 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19090919 | 0.89 | ALDH1A1 (0.63) | ALDH1A1KDM4EPOLBHPGDALOX15 | |
| SCHEMBL7679197 | 0.86 | ALDH1A1 (0.66) | ALDH1A1KDM4EPOLBHPGDALOX15 | |
| SCHEMBL4930304 | 0.86 | ALDH1A1 (0.66) | ALDH1A1KDM4EPOLBHPGDALOX15 | |
| SCHEMBL2570318 | 0.86 | ALDH1A1 (0.66) | ALDH1A1KDM4EPOLBHPGDALOX15 | |
| SCHEMBL19160257 | 0.84 | ALDH1A1 (0.71) | ALDH1A1KDM4EPOLBHPGDALOX15 | |
| SCHEMBL12376678 | 0.82 | ALDH1A1 (0.61) | ALDH1A1KDM4EPOLBHPGDALOX15 | |
| SCHEMBL13116111 | 0.82 | ALDH1A1 (0.61) | ALDH1A1KDM4EPOLBHPGDALOX15 | |
| SCHEMBL13101600 | 0.82 | ALDH1A1 (0.61) | ALDH1A1KDM4EPOLBHPGDALOX15 | |
| SCHEMBL63778 | 0.82 | ALDH1A1 (0.73) | ALDH1A1KDM4EPOLBHPGDALOX15 | |
| SCHEMBL8769978 | 0.81 | MAPT (0.70) | ALDH1A1KDM4EPOLBHPGDALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8324385-B2 | Diacylglycerol acyltransferase inhibitors | MADRIGAL PHARMACEUTICALS, INC. (US) | 2012-12-04 | — | — | US | disclosed |
| US-20100113782-A1 | Diacylglycerol Acyltransferase Inhibitors | MADRIGAL PHARMACEUTICALS, INC. | 2010-05-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100113782-A1 | Diacylglycerol Acyltransferase Inhibitors | DGAT2, DGAT1, MOGAT2 | ALDH1A1 802/4885KDM4E 3683/4885POLB 3823/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.