Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.46 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | THPO | P40225 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | BMP1 | P13497 | 3/20 | 0.38 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | TLR2 | O60603 | 2/20 | 0.37 |
| ▸ | GNPAT | O15228 | 1/20 | 0.37 |
| ▸ | MMP1 | P03956 | 2/20 | 0.36 |
| ▸ | MMP3 | P08254 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17623529 | 1.00 | SIRT6 (0.46) | SIRT6SIRT1KDM4EMAPTTHRB | |
| SCHEMBL13698293 | 0.89 | SIRT6 (0.55) | SIRT6SIRT1KDM4EMAPTTHRB | |
| SCHEMBL2789981 | 0.87 | SIRT6 (0.61) | SIRT6SIRT1CA1CA2TLR2 | |
| SCHEMBL13331678 | 0.87 | SIRT6 (0.61) | SIRT6SIRT1CA1CA2TLR2 | |
| SCHEMBL12365274 | 0.84 | SIRT6 (0.58) | SIRT6SIRT1CA1CA2TLR2 | |
| SCHEMBL15679192 | 0.83 | KDM4E (0.42) | SIRT6SIRT1KDM4EMAPTTHRB | |
| SCHEMBL17623530 | 0.82 | KDM4E (0.41) | SIRT6SIRT1KDM4EMAPTTHRB | |
| SCHEMBL27285928 | 0.82 | SIRT6 (0.44) | SIRT6SIRT1KDM4EMAPTTHRB | |
| SCHEMBL10442144 | 0.81 | GABRR1 (0.38) | BMP1MMP1MMP3MMP9GABRR1 | |
| SCHEMBL20366275 | 0.81 | GABRR1 (0.38) | BMP1MMP1MMP3MMP9GABRR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150209283-A1 | PROCESSES AND COMPOSITIONS FOR LIPOSOMAL AND EFFICIENT DELIVERY OF GENE SILENCING THERAPEUTICS | MARINA BIOTECH INC (US) | 2015-07-30 | — | — | US | disclosed |
| US-20130039970-A1 | Processes and Compositions for Liposomal and Efficient Delivery of Gene Silencing Therapeutics | MARINA BIOTECH, INC. (US) | 2013-02-14 | — | — | US | disclosed |
| US-20100112042-A1 | Processes and Compositions for Liposomal and Efficient Delivery of Gene Silencing Therapeutics | MDRNA, INC. (US) | 2010-05-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150209283-A1 | PROCESSES AND COMPOSITIONS FOR LIPOSOMAL AND EFFICIENT DELIVERY OF GENE SILENCING THERAPEUTICS | SLC27A2, LYPLA2, SLC27A1 | SIRT6 3814/4885SIRT1 4832/4885KDM4E 4127/4885 |
| US-20100112042-A1 | Processes and Compositions for Liposomal and Efficient Delivery of Gene Silencing Therapeutics | SLC27A2, LYPLA2, SLC47A2 | SIRT6 4366/4885SIRT1 4869/4885KDM4E 4573/4885 |
| US-20130039970-A1 | Processes and Compositions for Liposomal and Efficient Delivery of Gene Silencing Therapeutics | SLC27A2, LYPLA2, SLC27A1 | SIRT6 3814/4885SIRT1 4832/4885KDM4E 4127/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.