Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.72 |
| ▸ | SMO | Q99835 | 3/20 | 0.72 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.72 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.72 |
| ▸ | MEN1 | O00255 | 5/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.71 |
| ▸ | POLB | P06746 | 1/20 | 0.71 |
| ▸ | RAB9A | P51151 | 8/20 | 0.66 |
| ▸ | NPC1 | O15118 | 7/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.66 |
| ▸ | MIF | P14174 | 1/20 | 0.66 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.64 |
| ▸ | ALOX12 | P18054 | 4/20 | 0.64 |
| ▸ | LMNA | P02545 | 3/20 | 0.64 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1337488 | 0.94 | KCNK9 (0.81) | SMOKCNK9KCNK3MEN1KMT2A | |
| SCHEMBL1336273 | 0.91 | KCNK9 (0.70) | SMOKCNK9KCNK3MEN1KMT2A | |
| SCHEMBL1336791 | 0.91 | KCNK3 (0.73) | SMOKCNK9KCNK3MEN1KMT2A | |
| SCHEMBL1336746 | 0.89 | TRPV1 (0.76) | TRPV1SMOKCNK9KCNK3MEN1 | |
| SCHEMBL1337468 | 0.89 | KCNK9 (0.80) | SMOKCNK9KCNK3MEN1KMT2A | |
| SCHEMBL1335388 | 0.88 | RAB9A (0.70) | SMOKCNK9KCNK3MEN1KMT2A | |
| SCHEMBL1337740 | 0.88 | ALDH1A1 (0.67) | SMOKCNK9KCNK3MEN1KMT2A | |
| SCHEMBL12129902 | 0.88 | MEN1 (0.81) | SMOKCNK9KCNK3MEN1KMT2A | |
| SCHEMBL24769827 | 0.87 | RAB9A (0.74) | TRPV1SMOKCNK9KCNK3MEN1 | |
| SCHEMBL1336415 | 0.86 | KCNK3 (0.66) | SMOKCNK9KCNK3MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9073835-B2 | N-acylthiourea and N-acylurea inhibitors of the Hedgehog protein signalling pathway | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2015-07-07 | — | — | US | claimed |
| US-20110275663-A1 | N-Acylthiourea and N-Acylurea Inhibitors of the Hedgehog Protein Signalling Pathway | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2011-11-10 | — | — | US | claimed |
| EP-2291352-A2 | N-ACYLTHIOUREA AND N-ACYLUREA INHIBITORS OF THE HEDGEHOG PROTEIN SIGNALLING PATHWAY | Centre National de la Recherche Scientifique (FR) | 2011-03-09 | — | — | EP | claimed |
| WO-2009130422-A2 | N-ACYLTHIOUREA AND N-ACYLUREA INHIBITORS OF THE HEDGEHOG PROTEIN SIGNALLING PATHWAY | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2009-10-29 | — | — | WO | claimed |
| US-9073835-B2 | N-acylthiourea and N-acylurea inhibitors of the Hedgehog protein signalling pathway | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2015-07-07 | — | — | US | disclosed |
| US-20110275663-A1 | N-Acylthiourea and N-Acylurea Inhibitors of the Hedgehog Protein Signalling Pathway | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2011-11-10 | — | — | US | disclosed |
| EP-2291352-A2 | N-ACYLTHIOUREA AND N-ACYLUREA INHIBITORS OF THE HEDGEHOG PROTEIN SIGNALLING PATHWAY | Centre National de la Recherche Scientifique (FR) | 2011-03-09 | — | — | EP | disclosed |
| WO-2009130422-A2 | N-ACYLTHIOUREA AND N-ACYLUREA INHIBITORS OF THE HEDGEHOG PROTEIN SIGNALLING PATHWAY | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2009-10-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110275663-A1 | N-Acylthiourea and N-Acylurea Inhibitors of the Hedgehog Protein Signalling Pathway | SHH, GLI1, SMO | TRPV1 3310/4885SMO 3/4885KCNK9 4296/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.