Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.54 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | CASR | P41180 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30943481 | 0.82 | HPGD (0.57) | LOXL2ALOX5HPGDRAB9ACYP1A2 | |
| SCHEMBL1001902 | 0.82 | HPGD (0.57) | LOXL2ALOX5HPGDRAB9ACYP1A2 | |
| SCHEMBL999631 | 0.81 | HPGD (0.51) | LOXL2ALOX5HPGDRAB9ACYP1A2 | |
| SCHEMBL14413949 | 0.81 | HPGD (0.51) | LOXL2ALOX5HPGDRAB9ACYP1A2 | |
| SCHEMBL27285263 | 0.78 | HPGD (0.49) | LOXL2ALOX5HPGDRAB9ACYP1A2 | |
| SCHEMBL17947424 | 0.78 | HPGD (0.64) | LOXL2ALOX5HPGDRAB9ACYP1A2 | |
| SCHEMBL6240188 | 0.78 | LOXL2 (0.62) | LOXL2ALOX5HPGDRAB9ACYP1A2 | |
| SCHEMBL485998 | 0.78 | HPGD (0.64) | LOXL2ALOX5HPGDRAB9ACYP1A2 | |
| SCHEMBL12085830 | 0.78 | HPGD (0.64) | LOXL2ALOX5HPGDRAB9ACYP1A2 | |
| SCHEMBL2146969 | 0.77 | LOXL2 (0.66) | LOXL2ALOX5HPGDRAB9ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7723536-B2 | Synthetic techniques and intermediates for polyhydroxy dienyl lactones and mimics thereof | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2010-05-25 | — | — | US | disclosed |
| US-7652031-B2 | Compounds which mimic the chemical and biological properties of discodermolide | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2010-01-26 | — | — | US | disclosed |
| US-20090187031-A1 | Synthetic techniques and intermediates for polyhydroxy dienyl lactones and mimics thereof | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2009-07-23 | — | — | US | disclosed |
| US-7368585-B2 | Synthetic techniques and intermediates for polyhydroxy dienyl lactones and mimics thereof | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2008-05-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090187031-A1 | Synthetic techniques and intermediates for polyhydroxy dienyl lactones and mimics thereof | LSS, DHPS, ERG28 | LOXL2 844/4885ALOX5 1370/4885HPGD 181/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.