SCHEMBL19384261

SCHEMBL19384261

Brc1cccc(OC2CCOCC2)c1

nearest known ligand 0.58

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
SLC6A2 P23975 1/20 0.58
SLC6A4 P31645 1/20 0.58
SLC6A3 Q01959 1/20 0.58
MAOB P27338 3/20 0.39
HRH3 Q9Y5N1 1/20 0.37
SYK P43405 1/20 0.37
KAT2B Q92831 1/20 0.37
BAZ2B Q9UIF8 1/20 0.37
HRH1 P35367 1/20 0.37
PIK3CD O00329 1/20 0.36
LNPEP Q9UIQ6 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30748791 1.00 SLC6A2 (0.58) SLC6A2SLC6A4SLC6A3MAOBHRH3
SCHEMBL19384481 0.90 SLC6A2 (0.55) SLC6A2SLC6A4SLC6A3MAOBHRH3
SCHEMBL19384485 0.90 SLC6A2 (0.55) SLC6A2SLC6A4SLC6A3MAOBHRH3
SCHEMBL19384222 0.90 SLC6A2 (0.55) SLC6A2SLC6A4SLC6A3MAOBHRH3
SCHEMBL29711702 0.87 SLC6A4 (0.67) SLC6A2SLC6A4SLC6A3MAOBHRH1
SCHEMBL1416985 0.87 SLC6A4 (0.67) SLC6A2SLC6A4SLC6A3MAOBHRH1
SCHEMBL29735165 0.84 SLC6A4 (0.63) SLC6A2SLC6A4SLC6A3MAOBHRH1
SCHEMBL1438129 0.84 SLC6A4 (0.63) SLC6A2SLC6A4SLC6A3MAOBHRH1
SCHEMBL30124975 0.84 SLC6A2 (0.63) SLC6A2SLC6A4SLC6A3MAOBHRH1
SCHEMBL1337657 0.84 SLC6A2 (0.63) SLC6A2SLC6A4SLC6A3MAOBHRH1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210206758-A1 NAPHTHYRIDINES AS INTEGRIN ANTAGONISTS GLAXOSMITHKLINE IP DEV LTD (GB) 2021-07-08 US disclosed
US-20210206758-A1 NAPHTHYRIDINES AS INTEGRIN ANTAGONISTS GLAXOSMITHKLINE IP DEV LTD (GB) 2021-07-08 US disclosed
EP-3433254-B1 NAPHTHYRIDINES AS INTEGRIN ANTAGONISTS GLAXOSMITHKLINE IP DEV LTD (GB) 2020-06-17 EP disclosed
EP-3433254-B1 NAPHTHYRIDINES AS INTEGRIN ANTAGONISTS GLAXOSMITHKLINE IP DEV LTD (GB) 2020-06-17 EP disclosed
EP-3209664-B1 BICYCLIC HETEROARYL AMINE COMPOUNDS AS PI3K INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2020-06-03 EP disclosed
US-20190112306-A1 NAPHTHYRIDINES AS INTEGRIN ANTAGONISTS GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2019-04-18 US disclosed
US-20190112306-A1 NAPHTHYRIDINES AS INTEGRIN ANTAGONISTS GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2019-04-18 US disclosed
EP-3433255-A1 NAPHTHYRIDINES AS INTEGRIN ANTAGONISTS GlaxoSmithKline Intellectual Property Development Limited (GB) 2019-01-30 EP disclosed
EP-3433254-A1 NAPHTHYRIDINES AS INTEGRIN ANTAGONISTS GlaxoSmithKline Intellectual Property Development Limited (GB) 2019-01-30 EP disclosed
US-20170355707-A1 BICYCLIC HETEROARYL AMINE COMPOUNDS BRISTOL MYERS SQUIBB CO (US) 2017-12-14 US disclosed
US-20170355707-A1 BICYCLIC HETEROARYL AMINE COMPOUNDS BRISTOL MYERS SQUIBB CO (US) 2017-12-14 US disclosed
WO-2017162570-A1 NAPHTHYRIDINES AS INTEGRIN ANTAGONISTS GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2017-09-28 WO disclosed
WO-2017162572-A1 NAPHTHYRIDINES AS INTEGRIN ANTAGONISTS GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2017-09-28 WO disclosed
WO-2017162570-A1 NAPHTHYRIDINES AS INTEGRIN ANTAGONISTS GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2017-09-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210206758-A1 NAPHTHYRIDINES AS INTEGRIN ANTAGONISTS ITGB6, ITGA6, ITGB3 SLC6A2 500/4885SLC6A4 1457/4885SLC6A3 1081/4885
US-20170355707-A1 BICYCLIC HETEROARYL AMINE COMPOUNDS PIK3R3, JAK2, JAK3 SLC6A2 3622/4885SLC6A4 2991/4885SLC6A3 1069/4885
US-20190112306-A1 NAPHTHYRIDINES AS INTEGRIN ANTAGONISTS ITGB6, ITGA6, GP6 SLC6A2 531/4885SLC6A4 1492/4885SLC6A3 1108/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.