SCHEMBL13380239

SCHEMBL13380239

COc1ccc(/C(=C(/c2ccc(OC)cc2)c2ccc(C(F)(F)F)cc2)c2ccc(C(F)(F)F)cc2)cc1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A1 P04798 2/20 0.58
CYP1B1 Q16678 2/20 0.58
MAOB P27338 1/20 0.58
PTGS1 P23219 1/20 0.53
MAPT P10636 3/20 0.52
KDM4E B2RXH2 2/20 0.52
ALDH1A1 P00352 2/20 0.52
LMNA P02545 2/20 0.52
MAPK1 P28482 2/20 0.52
HSD17B10 Q99714 2/20 0.52
ESR1 P03372 1/20 0.52
ADORA3 P0DMS8 1/20 0.52
HPGD P15428 1/20 0.52
TSHR P16473 1/20 0.52
CYP2C19 P33261 1/20 0.52
ADRA1A P35348 1/20 0.52
SMN1; SMN2 Q16637 1/20 0.52
HIF1A Q16665 1/20 0.52
NPSR1 Q6W5P4 1/20 0.52
AHR P35869 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13380241 1.00 CYP1A1 (0.58) CYP1A1CYP1B1MAOBPTGS1MAPT
SCHEMBL13380341 0.93 MAPT (0.53) CYP1A1CYP1B1MAOBPTGS1MAPT
SCHEMBL255255 0.87 CA1 (0.58) CYP1A1CYP1B1MAOBPTGS1MAPK1
Hydrogen Sulfide SCHEMBL28878314 0.85 CA1 (0.55) CYP1A1CYP1B1MAOBPTGS1AHR
SCHEMBL25311192 0.85 CYP1A1 (0.63) CYP1A1CYP1B1MAOBMAPTKDM4E
SCHEMBL2957320 0.82 ALDH1A1 (0.70) MAPTKDM4EALDH1A1LMNAMAPK1
SCHEMBL22559002 0.82 PARP10 (0.72) CYP1A1CYP1B1MAOBMAPTKDM4E
SCHEMBL16626095 0.81 RAB9A (0.51) CYP1A1CYP1B1MAOBPTGS1AHR
SCHEMBL9064756 0.81 RAB9A (0.61) CYP1A1CYP1B1MAOBPTGS1MAPT
SCHEMBL3992142 0.81 KIF11 (0.54) CYP1A1CYP1B1MAOBAHRRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010047335-A1 BENZENE COMPOUND 国立大学法人京都大学 (JP) 2010-04-29 WO disclosed