Sugi Predict

Sugi Predict / Compounds / SCHEMBL25311192

SCHEMBL25311192

SCHEMBL25311192

COc1ccc(C(=O)c2ccc(C(F)(F)F)cc2)cc1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CYP1A1 P04798 2/20 0.63
▸ CYP1B1 Q16678 2/20 0.63
▸ MAOB P27338 1/20 0.63
▸ SRD5A2 P31213 2/20 0.61
▸ MAPT P10636 3/20 0.59
▸ MEN1 O00255 1/20 0.59
▸ LMNA P02545 1/20 0.59
▸ MAPK1 P28482 1/20 0.59
▸ RAB9A P51151 1/20 0.59
▸ KMT2A Q03164 1/20 0.59
▸ NPSR1 Q6W5P4 1/20 0.59
▸ RXFP1 Q9HBX9 1/20 0.59
▸ HPGD P15428 1/20 0.59
▸ ALDH1A1 P00352 1/20 0.54
▸ GAA P10253 1/20 0.54
▸ KDM4E B2RXH2 1/20 0.54
▸ CES2 O00748 2/20 0.53
▸ CES1 P23141 2/20 0.53
▸ TUBB4A P04350 1/20 0.53
▸ TUBB P07437 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22559002 0.86 PARP10 (0.72) CYP1A1CYP1B1MAOBMAPTKMT2A
SCHEMBL13380239 0.85 CYP1A1 (0.58) CYP1A1CYP1B1MAOBMAPTLMNA
SCHEMBL13380241 0.85 CYP1A1 (0.58) CYP1A1CYP1B1MAOBMAPTLMNA
SCHEMBL8058452 0.84 LMNA (0.63) CYP1A1CYP1B1MAOBMAPTLMNA
SCHEMBL16158172 0.84 MAOB (0.58) CYP1A1CYP1B1MAOBMAPTLMNA
SCHEMBL22130999 0.84 ALDH1A1 (0.73) CYP1A1CYP1B1MAOBMAPTLMNA
SCHEMBL8072562 0.84 LMNA (0.63) CYP1A1CYP1B1MAOBMAPTLMNA
SCHEMBL51509 0.84 RXFP1 (0.79) MAPTMEN1LMNAMAPK1RAB9A
SCHEMBL9418310 0.84 RXFP1 (0.79) MAPTMEN1LMNAMAPK1RAB9A
SCHEMBL255255 0.84 CA1 (0.58) CYP1A1CYP1B1MAOBMEN1MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118307410-A Preparation method of chiral secondary alcohol compound 武汉大学 2024-07-09 — — CN claimed
WO-2024019698-A1 PHOTOCATALYTIC SYNTHESIS OF ALPHA, BETA UNSATURATED CARBONYL COMPOUNDS AND THEIR INTERMEDIATES JSR CORPORATION (JP) 2024-01-25 — — WO claimed
US-12384780-B2 PARP1 inhibitors and uses thereof XINTHERA, INC. (US) 2025-08-12 — — US disclosed
CN-120081844-A PARP1 inhibitors and uses thereof 新特拉有限公司 2025-06-03 — — CN disclosed
CN-119824575-A Antifouling and biological adhesion-preventing PE/PTFE composite fiber and preparation method thereof 江苏金由新材料有限公司 2025-04-15 — — CN disclosed
CN-118804916-B PARP1 inhibitors and uses thereof 新特拉有限公司 2025-04-01 — — CN disclosed
CN-119350141-A Method for green synthesis of aromatic ketone and biphenyl based on quartz sand solid-phase system 华南师范大学 2025-01-24 — — CN disclosed
CN-119352190-A High-strength high-modulus wear-resistant thermotropic liquid crystal polyarylate composite fiber and preparation method thereof 东华大学 2025-01-24 — — CN disclosed
CN-119241477-A Synthesis method of functionalized carbon glycoside 武汉大学 2025-01-03 — — CN disclosed
CN-119243366-A Preparation and application of composite yarn of melt-spun polyethylene melt-coated thermotropic liquid crystal polyarylate fiber 东华大学 2025-01-03 — — CN disclosed
EP-4466269-A1 PARP1 INHIBITORS AND USES THEREOF Xinthera, Inc. (US) 2024-11-27 — — EP disclosed
US-20240368162-A1 PARP1 INHIBITORS AND USES THEREOF XINTHERA, INC. 2024-11-07 — — US disclosed
CN-118804916-A PARP1 inhibitors and uses thereof 新特拉有限公司 2024-10-18 — — CN disclosed
CN-118307410-A Preparation method of chiral secondary alcohol compound 武汉大学 2024-07-09 — — CN disclosed
CN-116178312-B Synthesis method of chiral cyclic ether 武汉大学 2024-06-25 — — CN disclosed
US-11939329-B2 PARP1 inhibitors and uses thereof XINTHERA, INC. (US) 2024-03-26 — — US disclosed
WO-2024019698-A1 PHOTOCATALYTIC SYNTHESIS OF ALPHA, BETA UNSATURATED CARBONYL COMPOUNDS AND THEIR INTERMEDIATES JSR CORPORATION (JP) 2024-01-25 — — WO disclosed
US-20230234952-A1 PARP1 INHIBITORS AND USES THEREOF XINTHERA, INC. 2023-07-27 — — US disclosed
WO-2023141290-A1 PARP1 INHIBITORS AND USES THEREOF XINTHERA, INC. (US) 2023-07-27 — — WO disclosed
CN-116178312-A Synthesis method of chiral cyclic ether 武汉大学 2023-05-30 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12384780-B2 PARP1 inhibitors and uses thereof PARP1, PARP11, PARP12 CYP1A1 3268/4885CYP1B1 3296/4885MAOB 2897/4885
US-11939329-B2 PARP1 inhibitors and uses thereof PARP1, PARP11, PARP12 CYP1A1 3268/4885CYP1B1 3296/4885MAOB 2897/4885
US-20230234952-A1 PARP1 INHIBITORS AND USES THEREOF PARP1, PARP11, PARP12 CYP1A1 3268/4885CYP1B1 3296/4885MAOB 2897/4885
US-20240368162-A1 PARP1 INHIBITORS AND USES THEREOF PARP1, PARP11, PARP12 CYP1A1 3268/4885CYP1B1 3296/4885MAOB 2897/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.