Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13381541 | 0.92 | TSHR (0.44) | TSHRTP53ALDH1A1GAA | |
| SCHEMBL13381703 | 0.88 | ADAM33 (0.52) | TSHRALDH1A1 | |
| SCHEMBL13381695 | 0.87 | L3MBTL1 (0.50) | TSHRALDH1A1GAA | |
| SCHEMBL2845581 | 0.84 | TP53 (0.58) | TP53 | |
| SCHEMBL13381709 | 0.82 | TSHR (0.48) | TSHRTP53ALDH1A1 | |
| SCHEMBL13381499 | 0.82 | ALDH1A1 (0.45) | TSHRALDH1A1GAA | |
| SCHEMBL13381622 | 0.82 | GAA (0.52) | TSHRALDH1A1GAA | |
| SCHEMBL13381708 | 0.82 | ALDH1A1 (0.49) | TSHRALDH1A1GAA | |
| SCHEMBL13381938 | 0.81 | TSHR (0.47) | TSHRALDH1A1 | |
| SCHEMBL13381698 | 0.81 | KMT2A (0.49) | TSHRALDH1A1GLAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010039911-A1 | CALCILYTIC COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-04-08 | — | — | WO | disclosed |