Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 12/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.44 |
| ▸ | GSK3B | P49841 | 2/20 | 0.44 |
| ▸ | CDC7 | O00311 | 1/20 | 0.44 |
| ▸ | PLK4 | O00444 | 1/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.44 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.44 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.44 |
| ▸ | PAK4 | O96013 | 1/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | INSR | P06213 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15882691 | 0.79 | DYRK1A (0.48) | AXLDYRK1AGSK3BCDC7PLK4 | |
| SCHEMBL22049462 | 0.79 | AXL (0.42) | AXLDYRK1AGSK3BCDC7PLK4 | |
| SCHEMBL15942804 | 0.79 | BRAF (0.45) | AXLDYRK1AGSK3BCDC7PLK4 | |
| SCHEMBL28489988 | 0.79 | JAK2 (0.48) | AXLDYRK1AGSK3BCDC7PLK4 | |
| SCHEMBL20584650 | 0.78 | AXL (0.71) | AXLDYRK1AGSK3BCDC7PLK4 | |
| SCHEMBL2671287 | 0.78 | AXL (0.45) | AXLITKCAMKK2SGK1 | |
| SCHEMBL30731289 | 0.78 | AXL (0.45) | AXLDYRK1AGSK3BCDC7PLK4 | |
| SCHEMBL29564788 | 0.78 | AXL (0.45) | AXLITKCAMKK2SGK1 | |
| SCHEMBL20319065 | 0.78 | AXL (0.45) | AXLDYRK1AITKCAMKK2SGK1 | |
| SCHEMBL22554109 | 0.78 | AXL (0.45) | AXLDYRK1AGSK3BCDC7PLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2699576-B1 | PYRAZOLOSPIROKETONE DERIVATIVES FOR USE AS ACETYL-COA CARBOXYLASE INHIBITORS | PFIZER (US) | 2015-12-09 | — | — | EP | disclosed |
| EP-2699576-B1 | PYRAZOLOSPIROKETONE DERIVATIVES FOR USE AS ACETYL-COA CARBOXYLASE INHIBITORS | PFIZER (US) | 2015-12-09 | — | — | EP | disclosed |
| US-20150336958-A1 | SUBSTITUTED ACETYL-COA CARBOXYLASE INHIBITORS | PFIZER INC. (US) | 2015-11-26 | — | — | US | disclosed |
| US-20150336958-A1 | SUBSTITUTED ACETYL-COA CARBOXYLASE INHIBITORS | PFIZER INC. (US) | 2015-11-26 | — | — | US | disclosed |
| US-20150112068-A1 | SUBSTITUTED ACETYL-COA CARBOXYLASE INHIBITORS | PFIZER INC. (US) | 2015-04-23 | — | — | US | disclosed |
| US-20150112068-A1 | SUBSTITUTED ACETYL-COA CARBOXYLASE INHIBITORS | PFIZER INC. (US) | 2015-04-23 | — | — | US | disclosed |
| US-20140323730-A1 | SUBSTITUTED ACETYL-COA CARBOXYLASE INHIBITORS | PFIZER (US) | 2014-10-30 | — | — | US | disclosed |
| US-20140323730-A1 | SUBSTITUTED ACETYL-COA CARBOXYLASE INHIBITORS | PFIZER (US) | 2014-10-30 | — | — | US | disclosed |
| US-8802688-B2 | Substituted acetyl-coa carboxylase inhibitors | PFIZER INC. (US) | 2014-08-12 | — | — | US | disclosed |
| US-8802688-B2 | Substituted acetyl-coa carboxylase inhibitors | PFIZER INC. (US) | 2014-08-12 | — | — | US | disclosed |
| EP-2699576-A1 | PYRAZOLOSPIROKETONE DERIVATIVES FOR USE AS ACETYL - COA CARBOXYLASE INHIBITORS | Pfizer Inc (US) | 2014-02-26 | — | — | EP | disclosed |
| WO-2012143813-A1 | PYRAZOLOSPIROKETONE DERIVATIVES FOR USE AS ACETYL - COA CARBOXYLASE INHIBITORS | PFIZER INC. (US) | 2012-10-26 | — | — | WO | disclosed |
| US-20120270893-A1 | SUBSTITUTED ACETYL-COA CARBOXYLASE INHIBITORS | PFIZER INC. (US) | 2012-10-25 | — | — | US | disclosed |
| US-20120270893-A1 | SUBSTITUTED ACETYL-COA CARBOXYLASE INHIBITORS | PFIZER INC. (US) | 2012-10-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150336958-A1 | SUBSTITUTED ACETYL-COA CARBOXYLASE INHIBITORS | ACACA, ACACB, ACAT1 | AXL 4690/4885DYRK1A 4223/4885GSK3B 319/4885 |
| US-20150112068-A1 | SUBSTITUTED ACETYL-COA CARBOXYLASE INHIBITORS | ACACA, ACACB, ACAT1 | AXL 4690/4885DYRK1A 4223/4885GSK3B 319/4885 |
| US-20140323730-A1 | SUBSTITUTED ACETYL-COA CARBOXYLASE INHIBITORS | ACACA, ACACB, ACAT1 | AXL 4724/4885DYRK1A 4172/4885GSK3B 326/4885 |
| US-20120270893-A1 | SUBSTITUTED ACETYL-COA CARBOXYLASE INHIBITORS | ACACA, ACACB, ACAT1 | AXL 4724/4885DYRK1A 4172/4885GSK3B 326/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.