Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.42 |
| ▸ | CCR6 | P51684 | 1/20 | 0.41 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1285759 | 0.88 | ALDH1A1 (0.51) | ALDH1A1MAPTHPGDSMN1; SMN2MAPK1 | |
| SCHEMBL13300890 | 0.85 | ALDH1A1 (0.49) | ALDH1A1MAPTHPGDSMN1; SMN2MAPK1 | |
| SCHEMBL23944461 | 0.84 | ALDH1A1 (0.55) | ALDH1A1MAPTHPGDSMN1; SMN2MAPK1 | |
| SCHEMBL25901621 | 0.83 | ALDH1A1 (0.53) | ALDH1A1MAPTHPGDSMN1; SMN2MAPK1 | |
| SCHEMBL13401595 | 0.82 | ALDH1A1 (0.46) | ALDH1A1MAPTHPGDSMN1; SMN2MAPK1 | |
| SCHEMBL7694380 | 0.80 | ALDH1A1 (0.62) | ALDH1A1MAPTHPGDMAPK1L3MBTL1 | |
| SCHEMBL22780788 | 0.80 | ALDH1A1 (0.50) | ALDH1A1MAPTHPGDSMN1; SMN2MAPK1 | |
| SCHEMBL22326382 | 0.80 | ALDH1A1 (0.50) | ALDH1A1MAPTHPGDSMN1; SMN2MAPK1 | |
| SCHEMBL8615968 | 0.78 | ALDH1A1 (0.47) | ALDH1A1MAPTHPGDSMN1; SMN2MAPK1 | |
| SCHEMBL25178599 | 0.78 | ALDH1A1 (0.47) | ALDH1A1MAPTHPGDSMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8906887-B2 | C7-fluoro substituted tetracycline compounds | TETRAPHASE PHARMACEUTICALS, INC. (US) | 2014-12-09 | — | — | US | disclosed |
| US-20100105671-A1 | C7-fluoro substituted tetracycline compounds | TETRAPHASE PHARMACEUTICALS, INC. | 2010-04-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100105671-A1 | C7-fluoro substituted tetracycline compounds | F7, TUBA1C, TUBA4A | ALDH1A1 1411/4885MAPT 422/4885HPGD 4789/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.