Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.77 |
| ▸ | GABRP | O00591 | 1/20 | 0.77 |
| ▸ | GABRD | O14764 | 1/20 | 0.77 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.77 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.77 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.77 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.77 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.77 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.77 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.77 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.77 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.77 |
| ▸ | GABRE | P78334 | 1/20 | 0.77 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.77 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.77 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.77 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.77 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.77 |
| ▸ | SLC6A1 | P30531 | 2/20 | 0.59 |
| ▸ | SLC6A11 | P48066 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29176774 | 0.93 | TSHR (0.65) | TSHRGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL13406400 | 0.93 | TSHR (0.81) | TSHRGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL444522 | 0.93 | TSHR (0.81) | TSHRGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL28415725 | 0.93 | TSHR (0.65) | TSHRGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL13406399 | 0.93 | TSHR (0.81) | TSHRGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL20504361 | 0.93 | TSHR (0.65) | TSHRGABRPGABRDGABRA1GABRB1 | |
| Hydrochloric Acid SCHEMBL12471116 | 0.91 | TSHR (0.77) | TSHRGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL13406402 | 0.88 | SLC6A1 (0.74) | TSHRGABRPGABRDGABRA1GABRB1 | |
| Isonipecotic Acid SCHEMBL104297 | 0.88 | — | — | |
| Isonipecotic Acid SCHEMBL2027408 | 0.88 | TSHR (1.00) | TSHRGABRPGABRDGABRA1GABRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102656179-A | Bufalin derivatives, pharmaceutical compositions and uses thereof | SUZHOU NEUPHARMA CO LTD | 2012-09-05 | — | — | CN | claimed |
| EP-4712961-A2 | KRAS G12S AND G12C INHIBITORS | Mirati Therapeutics, Inc. (US) | 2026-03-25 | — | — | EP | disclosed |
| WO-2024238633-A2 | KRAS G12S AND G12C INHIBITORS | Mirati Therapeutics, Inc. (US) | 2024-11-21 | — | — | WO | disclosed |
| CN-102656179-A | Bufalin derivatives, pharmaceutical compositions and uses thereof | SUZHOU NEUPHARMA CO LTD | 2012-09-05 | — | — | CN | disclosed |
| US-7700591-B2 | Benzoxazinyl-amidocyclopentyl-heterocyclic modulators of chemokine receptors | MERCK & CO., INC. (US) | 2010-04-20 | — | — | US | disclosed |
| US-7700591-B2 | Benzoxazinyl-amidocyclopentyl-heterocyclic modulators of chemokine receptors | MERCK & CO., INC. (US) | 2010-04-20 | — | — | US | disclosed |
| EP-1615699-B1 | BENZOXAZINYL-AMIDOCYCLOPENTYL-HETEROCYCLIC MODULATORS OF CHEMOKINE RECEPTORS | MERCK SHARP & DOHME (US) | 2010-03-24 | — | — | EP | disclosed |
| US-20070238723-A1 | Benzoxazinyl-amidocyclopentyl-heterocyclic modulators of chemokine receptors | GOBLE STEPHEN D | 2007-10-11 | — | — | US | disclosed |
| US-20070238723-A1 | Benzoxazinyl-amidocyclopentyl-heterocyclic modulators of chemokine receptors | GOBLE STEPHEN D | 2007-10-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070238723-A1 | Benzoxazinyl-amidocyclopentyl-heterocyclic modulators of chemokine receptors | CCR1, CCR2, CCRL2 | TSHR 501/4885GABRP 1485/4885GABRD 803/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.