Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.81 |
| ▸ | GABRP | O00591 | 1/20 | 0.81 |
| ▸ | GABRD | O14764 | 1/20 | 0.81 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.81 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.81 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.81 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.81 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.81 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.81 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.81 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.81 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.81 |
| ▸ | GABRE | P78334 | 1/20 | 0.81 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.81 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.81 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.81 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.81 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.81 |
| ▸ | SLC6A1 | P30531 | 2/20 | 0.68 |
| ▸ | SLC6A11 | P48066 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13406399 | 1.00 | TSHR (0.81) | TSHRGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL13406400 | 1.00 | TSHR (0.81) | TSHRGABRPGABRDGABRA1GABRB1 | |
| Hydrochloric Acid SCHEMBL12471116 | 0.98 | TSHR (0.77) | TSHRGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL13406402 | 0.95 | SLC6A1 (0.74) | TSHRGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL13406403 | 0.93 | TSHR (0.77) | TSHRGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL30712114 | 0.92 | TSHR (0.68) | TSHRGABRPGABRDGABRA1GABRB1 | |
| Isonipecotic Acid SCHEMBL2027408 | 0.90 | TSHR (1.00) | TSHRGABRPGABRDGABRA1GABRB1 | |
| Isonipecotic Acid SCHEMBL104297 | 0.90 | — | — | |
| Isonipecotic Acid SCHEMBL23043998 | 0.87 | TSHR (0.94) | TSHRGABRPGABRDGABRA1GABRB1 | |
| Isonipecotic Acid SCHEMBL1703706 | 0.87 | TSHR (0.94) | TSHRGABRPGABRDGABRA1GABRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 69 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11873291-B2 | Quinoline cGAS antagonist compounds | IMMUNESENSOR THERAPEUTICS, INC. (US) | 2024-01-16 | — | — | US | disclosed |
| CN-110446495-B | Delta opioid receptor modulating compounds containing 7-membered aza heterocycles and methods of use and preparation thereof | 特维娜有限公司 | 2023-09-05 | — | — | CN | disclosed |
| US-20220340893-A1 | BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | NUEVOLUTION A/S (DK) | 2022-10-27 | — | — | US | disclosed |
| US-11365199-B2 | Pyrazole compounds as modulators of FSHR and uses thereof | MERCK PATENT GMBH (DE) | 2022-06-21 | — | — | US | disclosed |
| US-11365199-B2 | Pyrazole compounds as modulators of FSHR and uses thereof | MERCK PATENT GMBH (DE) | 2022-06-21 | — | — | US | disclosed |
| CN-113874079-A | Bridged tricyclic carbamoylpyridone compounds and pharmaceutical use thereof | 吉利德科学公司 | 2021-12-31 | — | — | CN | disclosed |
| US-10894040-B2 | S1P modulating agents | BIOGEN MA INC. (US) | 2021-01-19 | — | — | US | disclosed |
| US-10894040-B2 | S1P modulating agents | BIOGEN MA INC. (US) | 2021-01-19 | — | — | US | disclosed |
| EP-3013832-B1 | PYRAZOLE COMPOUNDS AS MODULATORS OF FSHR AND USES THEREOF | MERCK PATENT GMBH (DE) | 2020-11-04 | — | — | EP | disclosed |
| EP-3660010-A1 | S1P MODULATING AGENTS | Biogen MA Inc. (US) | 2020-06-03 | — | — | EP | disclosed |
| US-20130236468-A1 | BENZODIOXANE INHIBITORS OF LEUKOTRIENE PRODUCTION FOR COMBINATION THERAPY | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-09-12 | — | — | US | disclosed |
| WO-2012109108-A1 | S1P MODULATING AGENTS | BIOGEN IDEC MA INC. (US) | 2012-08-16 | — | — | WO | disclosed |
| WO-2012109108-A1 | S1P MODULATING AGENTS | BIOGEN IDEC MA INC. (US) | 2012-08-16 | — | — | WO | disclosed |
| US-20120065188-A1 | SUBSTITUTED HETEROCYCLIC DERIVATIVES AND THEIR PHARMACEUTICAL USE AND COMPOSITIONS | PFIZER INC | 2012-03-15 | — | — | US | disclosed |
| US-20110092480-A1 | Substituted Heterocyclic Derivatives and Their Pharmaceutical Use and Compositions | PFIZER INC. | 2011-04-21 | — | — | US | disclosed |
| US-20070238721-A1 | Highly Selective Novel Amidation Method | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-10-11 | — | — | US | disclosed |
| CN-101001854-A | Highly selective novel amidation method | TAKEDA PHARMACEUTICAL (JP) | 2007-07-18 | — | — | CN | disclosed |
| CN-1942463-A | 2-aminopyridine derivative | ASTELLAS PHARMA INC (JP) | 2007-04-04 | — | — | CN | disclosed |
| EP-1753752-A1 | HIGHLY SELECTIVE NOVEL AMIDATION METHOD | Takeda Pharmaceutical Company Limited (JP) | 2007-02-21 | — | — | EP | disclosed |
| WO-2005121133-A1 | HIGHLY SELECTIVE NOVEL AMIDATION METHOD | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2005-12-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11365199-B2 | Pyrazole compounds as modulators of FSHR and uses thereof | FSHR, GNRHR, LHCGR | TSHR 10/4885GABRP 96/4885GABRD 292/4885 |
| US-11873291-B2 | Quinoline cGAS antagonist compounds | CGAS, GLS2, GLS | TSHR 2355/4885GABRP 1026/4885GABRD 1964/4885 |
| US-10894040-B2 | S1P modulating agents | S1PR2, S1PR1, S1PR3 | TSHR 638/4885GABRP 470/4885GABRD 2565/4885 |
| US-20070238721-A1 | Highly Selective Novel Amidation Method | NAAA, CPS1, COASY | TSHR 1811/4885GABRP 2517/4885GABRD 2834/4885 |
| US-20120065188-A1 | SUBSTITUTED HETEROCYCLIC DERIVATIVES AND THEIR PHARMACEUTICAL USE AND COMPOSITIONS | XDH, CYP2D6, F12 | TSHR 1567/4885GABRP 2870/4885GABRD 3570/4885 |
| US-20110092480-A1 | Substituted Heterocyclic Derivatives and Their Pharmaceutical Use and Compositions | XDH, CYP2D6, F12 | TSHR 1567/4885GABRP 2870/4885GABRD 3570/4885 |
| US-20130236468-A1 | BENZODIOXANE INHIBITORS OF LEUKOTRIENE PRODUCTION FOR COMBINATION THERAPY | LTB4R, LTB4R2, LTC4S | TSHR 2487/4885GABRP 2269/4885GABRD 1520/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.