Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.45 |
| ▸ | F2 | P00734 | 1/20 | 0.42 |
| ▸ | PLG | P00747 | 1/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.42 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.42 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 3/20 | 0.36 |
| ▸ | MAOA | P21397 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3147361 | 0.81 | F2 (0.50) | PBRM1F2PLGPRSS1PRSS2 | |
| SCHEMBL12171994 | 0.76 | TSHR (0.45) | F2PRSS1PRSS2PRSS3CA1 | |
| SCHEMBL14451448 | 0.71 | F2 (0.47) | PBRM1F2PLGPRSS1PRSS2 | |
| SCHEMBL16396188 | 0.70 | PBRM1 (0.59) | PBRM1F2PLGPRSS1PRSS2 | |
| SCHEMBL12326742 | 0.69 | PBRM1 (0.57) | PBRM1F2PLGPRSS1PRSS2 | |
| SCHEMBL14099468 | 0.68 | ALDH1A1 (0.34) | F2PRSS1PRSS2PRSS3MEN1 | |
| SCHEMBL19070659 | 0.67 | F2 (0.56) | PBRM1F2PLGPRSS1PRSS2 | |
| SCHEMBL20114738 | 0.66 | F2 (0.55) | PBRM1F2PLGPRSS1PRSS2 | |
| SCHEMBL9701403 | 0.66 | PBRM1 (0.63) | PBRM1F2PLGPRSS1PRSS2 | |
| SCHEMBL9975185 | 0.66 | LMNA (0.36) | MEN1KMT2AMAOBMAOAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100093768-A1 | Agents for Reversing Epigenetic Silencing of Genes | THE JOHNS HOPKINS UNIVERSITY | 2010-04-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100093768-A1 | Agents for Reversing Epigenetic Silencing of Genes | MECP2, MBD2, GATAD2B | PBRM1 563/4885F2 4881/4885PLG 4270/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.