Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.52 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.52 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.52 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.50 |
| ▸ | GRM5 | P41594 | 2/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.45 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1340964 | 1.00 | OPRM1 (0.52) | OPRM1OPRD1OPRK1P2RX7GRM5 | |
| SCHEMBL15967359 | 0.78 | OPRM1 (0.54) | OPRM1OPRD1OPRK1P2RX7GRM5 | |
| Hydrochloric Acid SCHEMBL708457 | 0.77 | OPRM1 (0.53) | OPRM1OPRD1OPRK1P2RX7GRM5 | |
| SCHEMBL2925127 | 0.77 | OPRM1 (0.47) | OPRM1OPRD1OPRK1CACNA1HL3MBTL1 | |
| SCHEMBL2925124 | 0.77 | OPRM1 (0.47) | OPRM1OPRD1OPRK1CACNA1HL3MBTL1 | |
| SCHEMBL8209794 | 0.74 | MAPT (0.50) | OPRK1GRM5L3MBTL1NPC1RAB9A | |
| SCHEMBL7397494 | 0.72 | P2RX7 (0.54) | OPRM1OPRD1OPRK1P2RX7GRM5 | |
| SCHEMBL3776499 | 0.71 | CACNA1H (0.49) | OPRM1OPRD1OPRK1P2RX7KCNH2 | |
| SCHEMBL1339673 | 0.71 | HCRTR1 (0.43) | OPRM1OPRK1CACNA1HNPC1ALDH1A1 | |
| SCHEMBL13176296 | 0.71 | HCRTR1 (0.43) | OPRM1OPRK1CACNA1HNPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8063099-B2 | Trans-3-aza-bicyclo[3.1.0]hexane derivatives | ACTELION PHARMACEUTICALS LTD. (CH) | 2011-11-22 | — | — | US | disclosed |
| EP-2185512-B1 | TRANS-3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-12-29 | — | — | EP | disclosed |
| US-20100204285-A1 | TRANS-3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES | ACTELION PHARMACEUTICALS LTD. (CH) | 2010-08-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100204285-A1 | TRANS-3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES | HCRTR1, HCRTR2, CNR1 | OPRM1 121/4885OPRD1 59/4885OPRK1 162/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.