Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.50 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.50 |
| ▸ | GRM5 | P41594 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.46 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8025278 | 0.76 | GRM5 (0.59) | GAAGRM5ALDH1A1L3MBTL1NPC1 | |
| SCHEMBL18942350 | 0.74 | OPRM1 (0.47) | P2RX7OPRM1OPRD1OPRK1GRM5 | |
| SCHEMBL15967359 | 0.74 | OPRM1 (0.54) | P2RX7OPRM1OPRD1OPRK1GRM5 | |
| SCHEMBL2984329 | 0.73 | KMT2A (0.60) | P2RX7ALDH1A1MEN1KMT2AKCNK3 | |
| Hydrochloric Acid SCHEMBL708457 | 0.73 | OPRM1 (0.53) | P2RX7OPRM1OPRD1OPRK1GRM5 | |
| SCHEMBL17730182 | 0.73 | CRHR1 (0.58) | P2RX7OPRM1OPRD1OPRK1GRM5 | |
| SCHEMBL17730181 | 0.73 | CRHR1 (0.58) | P2RX7OPRM1OPRD1OPRK1GRM5 | |
| SCHEMBL16506712 | 0.72 | KMO (0.64) | GAAGRM5ALDH1A1L3MBTL1NPC1 | |
| SCHEMBL8008231 | 0.72 | KMO (0.64) | GAAGRM5ALDH1A1L3MBTL1NPC1 | |
| SCHEMBL1340964 | 0.72 | OPRM1 (0.52) | P2RX7OPRM1OPRD1OPRK1GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1189873-A1 | EXCITATORY AMINO ACID RECEPTOR MODULATORS | Lilly, S.A. (ES) | 2002-03-27 | — | — | EP | disclosed |
| WO-2000075101-A1 | EXCITATORY AMINO ACID RECEPTOR MODULATORS | LILLY, S.A. (ES) | 2000-12-14 | — | — | WO | disclosed |