Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTTP | P55157 | 6/20 | 0.47 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.45 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.45 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | KLRK1 | P26718 | 1/20 | 0.42 |
| ▸ | MICA | Q29983 | 1/20 | 0.42 |
| ▸ | UBE2M | P61081 | 3/20 | 0.41 |
| ▸ | DCUN1D1 | Q96GG9 | 3/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | MLNR | O43193 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13419471 | 0.95 | MTTP (0.47) | MTTPHCRTR1HCRTR2FAAHKLRK1 | |
| SCHEMBL13419184 | 0.92 | MTTP (0.53) | MTTPHCRTR1HCRTR2FAAHKLRK1 | |
| SCHEMBL13419138 | 0.92 | CYP2C9 (0.52) | MTTPHCRTR1HCRTR2FAAHCYP2C9 | |
| SCHEMBL5796728 | 0.91 | MTTP (0.54) | MTTPHCRTR1HCRTR2FAAHKLRK1 | |
| SCHEMBL13419205 | 0.91 | MTTP (0.54) | MTTPHCRTR1HCRTR2FAAHKLRK1 | |
| SCHEMBL13419201 | 0.90 | FAAH (0.48) | MTTPHCRTR1HCRTR2FAAHUBE2M | |
| SCHEMBL13419083 | 0.90 | HTR2C (0.48) | MTTPHCRTR1HCRTR2FAAHCYP2C9 | |
| SCHEMBL13419545 | 0.90 | MTTP (0.51) | MTTPHCRTR1HCRTR2FAAHUBE2M | |
| SCHEMBL13419084 | 0.89 | MTTP (0.49) | MTTPHCRTR1HCRTR2FAAHUBE2M | |
| SCHEMBL5751912 | 0.89 | GAA (0.48) | MTTPHCRTR1HCRTR2FAAHUBE2M |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7674803-B2 | Thiazolypiperidine derivatives as MTP inhibitors | MERCK PATENT GMBH (DE) | 2010-03-09 | — | — | US | disclosed |
| US-7674803-B2 | Thiazolypiperidine derivatives as MTP inhibitors | MERCK PATENT GMBH (DE) | 2010-03-09 | — | — | US | disclosed |