Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | MTTP | P55157 | 6/20 | 0.48 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.44 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | UBE2M | P61081 | 2/20 | 0.40 |
| ▸ | DCUN1D1 | Q96GG9 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13419545 | 0.92 | MTTP (0.51) | MTTPHCRTR1HCRTR2ALDH1A1FAAH | |
| SCHEMBL13419184 | 0.91 | MTTP (0.53) | MTTPHCRTR1HCRTR2ALDH1A1FAAH | |
| SCHEMBL13419155 | 0.91 | MTTP (0.47) | MTTPHCRTR1HCRTR2FAAHUBE2M | |
| SCHEMBL5796728 | 0.90 | MTTP (0.54) | MTTPHCRTR1HCRTR2FAAHUBE2M | |
| SCHEMBL13419205 | 0.90 | MTTP (0.54) | MTTPHCRTR1HCRTR2FAAHUBE2M | |
| SCHEMBL13419201 | 0.90 | FAAH (0.48) | MTTPHCRTR1HCRTR2FAAHUBE2M | |
| SCHEMBL13419465 | 0.89 | MTTP (0.48) | GAATDP1MTTPHCRTR1HCRTR2 | |
| SCHEMBL13419083 | 0.89 | HTR2C (0.48) | MTTPHCRTR1HCRTR2FAAHSMN1; SMN2 | |
| SCHEMBL13419477 | 0.89 | MTTP (0.47) | MTTPHCRTR1HCRTR2FAAHTRPV1 | |
| SCHEMBL13419471 | 0.89 | MTTP (0.47) | MTTPHCRTR1HCRTR2FAAHUBE2M |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7674803-B2 | Thiazolypiperidine derivatives as MTP inhibitors | MERCK PATENT GMBH (DE) | 2010-03-09 | — | — | US | disclosed |
| US-7674803-B2 | Thiazolypiperidine derivatives as MTP inhibitors | MERCK PATENT GMBH (DE) | 2010-03-09 | — | — | US | disclosed |
| EP-1636218-A1 | THIAZOLYLPIPERIDINE DERIVATIVES AS MTP INHIBITORS | MERCK PATENT GmbH (DE) | 2006-03-22 | — | — | EP | disclosed |
| WO-2005003128-A1 | THIAZOLYLPIPERIDINE DERIVATIVES AS MTP INHIBITORS | MERCK PATENT GMBH (DE) | 2005-01-13 | — | — | WO | disclosed |