Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 1/20 | 0.52 |
| ▸ | BAZ2A | Q9UIF9 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | PLAT | P00750 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7258954 | 0.83 | HPGDS (0.49) | HPGDSBAZ2AAOC3 | |
| SCHEMBL4262100 | 0.79 | HPGDS (0.59) | HPGDSBAZ2AALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL13422220 | 0.78 | HPGDS (0.52) | HPGDSBAZ2AALDH1A1SMN1; SMN2MEN1 | |
| Bromide SCHEMBL2983628 | 0.78 | HPGDS (0.57) | HPGDSBAZ2AALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL12620735 | 0.78 | BAZ2A (0.45) | HPGDSBAZ2AMEN1KMT2AAOC3 | |
| SCHEMBL4262470 | 0.76 | HPGDS (0.52) | HPGDSBAZ2AMEN1KMT2AAOC3 | |
| SCHEMBL2297392 | 0.76 | HPGDS (0.78) | HPGDSBAZ2AALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL4265265 | 0.76 | HPGDS (0.61) | HPGDSBAZ2AALDH1A1SMN1; SMN2MEN1 | |
| Bromide SCHEMBL2983703 | 0.75 | HPGDS (0.51) | HPGDSBAZ2AMEN1KMT2AAOC3 | |
| Hydrochloric Acid SCHEMBL3768256 | 0.74 | HPGDS (0.76) | HPGDSBAZ2AALDH1A1SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7674803-B2 | Thiazolypiperidine derivatives as MTP inhibitors | MERCK PATENT GMBH (DE) | 2010-03-09 | — | — | US | disclosed |
| US-7674803-B2 | Thiazolypiperidine derivatives as MTP inhibitors | MERCK PATENT GMBH (DE) | 2010-03-09 | — | — | US | disclosed |
| EP-1636218-B1 | THIAZOLYLPIPERIDINE DERIVATIVES AS MTP INHIBITORS | MERCK PATENT GMBH (DE) | 2009-03-25 | — | — | EP | disclosed |
| US-20070054939-A1 | Thiazolypiperidine derivatives as mtp inhibitors | MERCK PATNET GMBH (DE) | 2007-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070054939-A1 | Thiazolypiperidine derivatives as mtp inhibitors | MTTP, CETP, APOB | HPGDS 537/4885BAZ2A 2981/4885ALDH1A1 955/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.