Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 14/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | GMNN | O75496 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TTR | P02766 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12856595 | 0.91 | PDK2 (0.48) | PDK2MAPK14KDM4EMEN1GMNN | |
| SCHEMBL13423240 | 0.85 | PDK2 (0.50) | PDK2TDP1 | |
| SCHEMBL13423248 | 0.85 | PDK2 (0.43) | PDK2MAPK14MEN1MAPTTHRB | |
| SCHEMBL13423255 | 0.85 | PDK2 (0.43) | PDK2MAPK14MEN1MAPTTHRB | |
| SCHEMBL13423253 | 0.84 | BCL2 (0.44) | PDK2MEN1MAPTKMT2ATDP1 | |
| SCHEMBL13423252 | 0.82 | PDK2 (0.58) | PDK2MEN1ALDH1A1CYP2C9RAB9A | |
| SCHEMBL13423232 | 0.82 | PDK2 (0.58) | PDK2MEN1ALDH1A1CYP2C9RAB9A | |
| SCHEMBL13423239 | 0.82 | PDK2 (0.48) | PDK2TDP1 | |
| SCHEMBL13423257 | 0.82 | PDK2 (0.58) | PDK2MEN1ALDH1A1CYP2C9RAB9A | |
| SCHEMBL13423246 | 0.81 | PDK2 (0.57) | PDK2MEN1ALDH1A1CYP2C9RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7683229-B2 | truxene and isotruxene derivatives, in particular spirotruxene and spiroisotruxene derivatives; use thereof in organic electronic devices, in particular organic electroluminescent devices | MERCK PATENT GMBH (DE) | 2010-03-23 | — | — | US | disclosed |
| US-20080093980-A1 | Organic Electroluminescent Device | MERCK PATENT GMBH (DE) | 2008-04-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080093980-A1 | Organic Electroluminescent Device | OXER1, NR3C2, OXTR | PDK2 921/4885MAPK14 2070/4885KDM4E 4483/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.