Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 9/20 | 0.43 |
| ▸ | CYP2C8 | P10632 | 2/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | HNF4A | P41235 | 1/20 | 0.40 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CDC25B | P30305 | 2/20 | 0.37 |
| ▸ | CDC25A | P30304 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13423248 | 1.00 | PDK2 (0.43) | PDK2CYP2C8MAPK13MAPK12MAPK11 | |
| SCHEMBL29307110 | 0.91 | PDK2 (0.48) | PDK2CYP2C8MAPK13MAPK12MAPK11 | |
| SCHEMBL14096680 | 0.87 | ALDH1A1 (0.40) | PDK2CYP2C8MAPK13MAPK12MAPK11 | |
| SCHEMBL13423252 | 0.85 | PDK2 (0.58) | PDK2CYP2C8MEN1KMT2AATM | |
| SCHEMBL13423232 | 0.85 | PDK2 (0.58) | PDK2CYP2C8MEN1KMT2AATM | |
| SCHEMBL13423257 | 0.85 | PDK2 (0.58) | PDK2CYP2C8MEN1KMT2AATM | |
| SCHEMBL13423240 | 0.85 | PDK2 (0.50) | PDK2ATMTDP1 | |
| SCHEMBL13423247 | 0.85 | PDK2 (0.43) | PDK2MAPK14MEN1KMT2AMAPT | |
| SCHEMBL13423246 | 0.84 | PDK2 (0.57) | PDK2CYP2C8MEN1KMT2AATM | |
| SCHEMBL13423253 | 0.84 | BCL2 (0.44) | PDK2MEN1KMT2AMAPTCDC25B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7683229-B2 | truxene and isotruxene derivatives, in particular spirotruxene and spiroisotruxene derivatives; use thereof in organic electronic devices, in particular organic electroluminescent devices | MERCK PATENT GMBH (DE) | 2010-03-23 | — | — | US | disclosed |
| US-20080093980-A1 | Organic Electroluminescent Device | MERCK PATENT GMBH (DE) | 2008-04-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080093980-A1 | Organic Electroluminescent Device | OXER1, NR3C2, OXTR | PDK2 921/4885CYP2C8 1976/4885MAPK13 2255/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.