Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | RXRA | P19793 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 6/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.32 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.32 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.32 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.32 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13425366 | 0.72 | PTPN1 (0.42) | HTTOPRK1RXRAHPGDALDH1A1 | |
| SCHEMBL3375374 | 0.70 | AKR1C3 (0.54) | AKR1B10MMP2AKR1B1AKR1C3PAK1 | |
| SCHEMBL3934429 | 0.65 | HTT (0.49) | HTTHPGDALDH1A1PTPN1AKR1B10 | |
| SCHEMBL30392193 | 0.64 | HTT (0.55) | HTTHPGDALDH1A1PTPN1TDP1 | |
| SCHEMBL8346381 | 0.63 | HTT (0.58) | HTTHPGDALDH1A1PTPN1AKR1B10 | |
| SCHEMBL4742841 | 0.63 | PTPN1 (0.48) | HTTHPGDALDH1A1PTPN1TDP1 | |
| SCHEMBL1607531 | 0.61 | HTT (0.79) | HTTHPGDALDH1A1PTPN1AKR1B10 | |
| SCHEMBL30392187 | 0.61 | HTT (0.79) | HTTHPGDALDH1A1PTPN1AKR1B10 | |
| SCHEMBL16224828 | 0.61 | AKR1B10 (0.46) | HTTHPGDALDH1A1PTPN1AKR1B10 | |
| SCHEMBL6522857 | 0.59 | BACE1 (0.56) | PTPN1AKR1B10MMP2AKR1B1AKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9144539-B2 | Methioninase inhibitor and composition and food or drink containing the same | Lotte Co, Ltd. (JP) | 2015-09-29 | — | — | US | disclosed |
| US-9144539-B2 | Methioninase inhibitor and composition and food or drink containing the same | Lotte Co, Ltd. (JP) | 2015-09-29 | — | — | US | disclosed |
| US-20140308218-A1 | METHIONINASE INHIBITOR AND COMPOSITION AND FOOD OR DRINK CONTAINING THE SAME | LOTTE CO LTD (JP) | 2014-10-16 | — | — | US | disclosed |
| US-20140308218-A1 | METHIONINASE INHIBITOR AND COMPOSITION AND FOOD OR DRINK CONTAINING THE SAME | LOTTE CO LTD (JP) | 2014-10-16 | — | — | US | disclosed |
| US-20100069477-A1 | METHIONINASE INHIBITOR AND COMPOSITION AND FOOD OR DRINK CONTAINING THE SAME | LOTTE CO., LTD. (JP) | 2010-03-18 | — | — | US | disclosed |
| US-20100069477-A1 | METHIONINASE INHIBITOR AND COMPOSITION AND FOOD OR DRINK CONTAINING THE SAME | LOTTE CO., LTD. (JP) | 2010-03-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100069477-A1 | METHIONINASE INHIBITOR AND COMPOSITION AND FOOD OR DRINK CONTAINING THE SAME | MAT2A, SMS, MAT2B | HTT 1440/4885OPRK1 4031/4885RXRA 4721/4885 |
| US-20140308218-A1 | METHIONINASE INHIBITOR AND COMPOSITION AND FOOD OR DRINK CONTAINING THE SAME | MAT2A, SMS, MAT2B | HTT 1440/4885OPRK1 4031/4885RXRA 4721/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.