Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 7/20 | 0.42 |
| ▸ | RXRA | P19793 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | ODC1 | P11926 | 1/20 | 0.33 |
| ▸ | OSBP | P22059 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | APP | P05067 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29870166 | 0.79 | TDP1 (0.46) | PTPN1RXRAALOX5ALOX15ALOX12 | |
| SCHEMBL29870167 | 0.79 | TDP1 (0.46) | PTPN1RXRAALOX5ALOX15ALOX12 | |
| SCHEMBL13425367 | 0.72 | PTPN1 (0.44) | PTPN1RXRAALOX5ALOX15HTT | |
| SCHEMBL13425369 | 0.72 | HTT (0.36) | PTPN1RXRAHTTOPRK1ALDH1A1 | |
| SCHEMBL17877817 | 0.71 | OPRM1 (0.41) | PTPN1OPRK1OPRM1 | |
| SCHEMBL31058467 | 0.70 | PTPN1 (0.39) | PTPN1RXRAALOX5 | |
| SCHEMBL15249294 | 0.70 | PTPN1 (0.39) | PTPN1RXRAALOX5 | |
| SCHEMBL15397968 | 0.70 | AKR1C3 (0.54) | PTPN1RXRAALOX5OSBP | |
| SCHEMBL15397966 | 0.70 | AKR1C3 (0.54) | PTPN1RXRAALOX5OSBP | |
| SCHEMBL4742841 | 0.68 | PTPN1 (0.48) | PTPN1ALOX5HTTODC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9144539-B2 | Methioninase inhibitor and composition and food or drink containing the same | Lotte Co, Ltd. (JP) | 2015-09-29 | — | — | US | disclosed |
| US-9144539-B2 | Methioninase inhibitor and composition and food or drink containing the same | Lotte Co, Ltd. (JP) | 2015-09-29 | — | — | US | disclosed |
| US-20140308218-A1 | METHIONINASE INHIBITOR AND COMPOSITION AND FOOD OR DRINK CONTAINING THE SAME | LOTTE CO LTD (JP) | 2014-10-16 | — | — | US | disclosed |
| US-20140308218-A1 | METHIONINASE INHIBITOR AND COMPOSITION AND FOOD OR DRINK CONTAINING THE SAME | LOTTE CO LTD (JP) | 2014-10-16 | — | — | US | disclosed |
| US-20100069477-A1 | METHIONINASE INHIBITOR AND COMPOSITION AND FOOD OR DRINK CONTAINING THE SAME | LOTTE CO., LTD. (JP) | 2010-03-18 | — | — | US | disclosed |
| US-20100069477-A1 | METHIONINASE INHIBITOR AND COMPOSITION AND FOOD OR DRINK CONTAINING THE SAME | LOTTE CO., LTD. (JP) | 2010-03-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100069477-A1 | METHIONINASE INHIBITOR AND COMPOSITION AND FOOD OR DRINK CONTAINING THE SAME | MAT2A, SMS, MAT2B | PTPN1 3193/4885RXRA 4721/4885ALOX5 2307/4885 |
| US-20140308218-A1 | METHIONINASE INHIBITOR AND COMPOSITION AND FOOD OR DRINK CONTAINING THE SAME | MAT2A, SMS, MAT2B | PTPN1 3193/4885RXRA 4721/4885ALOX5 2307/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.