SCHEMBL13429477

SCHEMBL13429477

O[Si](O)(O)c1ccc(Br)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 1/20 0.50
ALOX15 P16050 2/20 0.45
CA1 P00915 3/20 0.39
CA2 P00918 3/20 0.39
TSHR P16473 1/20 0.39
CES2 O00748 1/20 0.39
CES1 P23141 1/20 0.39
ALDH1A1 P00352 4/20 0.38
MAPK1 P28482 2/20 0.38
LMNA P02545 1/20 0.36
TDP1 Q9NUW8 1/20 0.35
SLC22A2 O15244 1/20 0.35
SLC22A1 O15245 1/20 0.35
SLC22A3 O75751 1/20 0.35
PLAU P00749 1/20 0.35
GLB1 P16278 1/20 0.35
CTRB1 P17538 1/20 0.35
CTRC Q99895 1/20 0.35
NOS1 P29475 2/20 0.33
GSK3B P49841 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL272403 0.83 ESR1 (0.30)
SCHEMBL11419129 0.81 CYP2A6 (0.50) CYP2A6ALOX15CA1CA2TSHR
SCHEMBL18692032 0.77 CYP2A6 (0.44) CYP2A6ALOX15CA1CA2TSHR
SCHEMBL6433749 0.73 ESR1 (0.39) ALDH1A1LMNATDP1
SCHEMBL697060 0.73 CYP2A6 (0.57) CYP2A6ALOX15CA1CA2TSHR
SCHEMBL17937682 0.71 CYP2A6 (0.53) CYP2A6ALOX15CA1CA2TSHR
SCHEMBL18508 0.71
SCHEMBL4513203 0.69 MAPT (0.50) ALOX15TSHRALDH1A1MAPK1LMNA
SCHEMBL13610368 0.69 CYP2A6 (0.50) CYP2A6ALOX15CA1CA2TSHR
SCHEMBL1686464 0.69 ACHE (0.50) CA1CA2TSHRCES2CES1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100069603-A1 METHOD FOR PRODUCING STRUCTURE WHEREIN AROMATIC POLYMER IS BONDED TO BASE, STRUCTURE HAVING AROMATIC POLYMER CHAIN BONDED TO CONDUCTIVE BASE, AND ELECTRONIC DEVICE COMPRISING THE STRUCTURE SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2010-03-18 US disclosed