Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | DDAH1 | O94760 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | SLC1A5 | Q15758 | 1/20 | 0.35 |
| ▸ | PARP15 | Q460N3 | 2/20 | 0.35 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.35 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1342933 | 0.88 | ADRB2 (0.42) | ALDH1A1KMT2AHPGDSMN1; SMN2KDM4E | |
| SCHEMBL1344939 | 0.85 | SLC1A3 (0.45) | LMNASMN1; SMN2DDAH1 | |
| SCHEMBL1345511 | 0.82 | KDM4E (0.39) | ALDH1A1KMT2AHPGDSMN1; SMN2KDM4E | |
| SCHEMBL1345111 | 0.80 | CTSD (0.39) | DDAH1 | |
| SCHEMBL1344948 | 0.79 | POLB (0.45) | ALDH1A1KMT2AHPGDKDM4EDDAH1 | |
| SCHEMBL1345420 | 0.78 | DDAH1 (0.47) | ALDH1A1KMT2ADDAH1GAACYP2C19 | |
| SCHEMBL1345053 | 0.78 | FDFT1 (0.42) | LMNA | |
| SCHEMBL1343488 | 0.78 | DDAH1 (0.43) | ALDH1A1HPGDDDAH1GAACYP2C19 | |
| SCHEMBL1343296 | 0.77 | DDAH1 (0.43) | ALDH1A1DDAH1GAA | |
| SCHEMBL1345238 | 0.74 | DDAH1 (0.44) | DDAH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8063104-B2 | Guanidine derivatives as inhibitors of DDAH | UCL BUSINESS PLC (GB) | 2011-11-22 | — | — | US | disclosed |