Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SLC1A5 | Q15758 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | MMP12 | P39900 | 1/20 | 0.36 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | DDAH1 | O94760 | 2/20 | 0.35 |
| ▸ | IDO1 | P14902 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.35 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.35 |
| ▸ | C3AR1 | Q16581 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1345511 | 0.89 | KDM4E (0.39) | MEN1KMT2AMMP2MMP9MMP12 | |
| SCHEMBL1344939 | 0.89 | SLC1A3 (0.45) | DDAH1SLC1A3SLC1A1SCN5ASCN2A | |
| SCHEMBL1345099 | 0.87 | PRKCA (0.41) | SLC1A5MMP12GPBAR1ALDH1A1GAA | |
| SCHEMBL1345053 | 0.87 | FDFT1 (0.42) | MMP2MMP9MMP12 | |
| SCHEMBL1344678 | 0.82 | SCNN1A (0.43) | KMT2AALDH1A1GAAMAPTDDAH1 | |
| SCHEMBL1345111 | 0.81 | CTSD (0.39) | DDAH1 | |
| SCHEMBL1343488 | 0.79 | DDAH1 (0.43) | ALDH1A1GAAMAPTHPGDDDAH1 | |
| SCHEMBL1342933 | 0.79 | ADRB2 (0.42) | POLBMEN1KMT2AALDH1A1GAA | |
| SCHEMBL1345420 | 0.78 | DDAH1 (0.47) | MEN1KMT2AALDH1A1GAAMAPT | |
| SCHEMBL1343518 | 0.76 | CA12 (0.46) | MAPTPADI4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8063104-B2 | Guanidine derivatives as inhibitors of DDAH | UCL BUSINESS PLC (GB) | 2011-11-22 | — | — | US | disclosed |