Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FEN1 | P39748 | 3/20 | 0.53 |
| ▸ | DAO | P14920 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | COMT | P21964 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13402676 | 0.84 | FEN1 (0.56) | FEN1SLC6A2HTTHPGDCYP1A2 | |
| SCHEMBL13402864 | 0.83 | FEN1 (0.44) | FEN1SLC6A2HTTHPGDCYP1A2 | |
| SCHEMBL3518030 | 0.80 | FEN1 (0.49) | FEN1HTTHPGDNPC1ALDH1A1 | |
| SCHEMBL10412161 | 0.79 | FEN1 (0.58) | FEN1CYP2C19ALDH1A1NPSR1 | |
| SCHEMBL13461600 | 0.78 | FEN1 (0.47) | FEN1DAOHPGDNPC1HSP90AA1 | |
| SCHEMBL13435249 | 0.77 | FEN1 (0.46) | FEN1DAOHTTCYP1A2NPC1 | |
| SCHEMBL16250051 | 0.77 | FEN1 (0.49) | FEN1DAOHPGDNPC1ALDH1A1 | |
| SCHEMBL3514828 | 0.77 | FEN1 (0.46) | FEN1HPGDNPC1ALDH1A1KDM4E | |
| SCHEMBL3517675 | 0.77 | CNR2 (0.47) | FEN1HTTHPGDNPC1ALDH1A1 | |
| SCHEMBL3514525 | 0.77 | ALDH1A1 (0.55) | HTTHPGDALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100056516-A1 | 1-HYDROXY NAPHTHYRIDINE COMPOUNDS AS ANTI-HIV AGENTS | MERCK SHARP & DOHME CORP. | 2010-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100056516-A1 | 1-HYDROXY NAPHTHYRIDINE COMPOUNDS AS ANTI-HIV AGENTS | RNASEH1, RNASE1, RNASEL | FEN1 115/4885DAO 3247/4885SLC6A2 2805/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.