Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.47 |
| ▸ | CSNK2A1 | P68400 | 4/20 | 0.47 |
| ▸ | PIM1 | P11309 | 4/20 | 0.47 |
| ▸ | PIM3 | Q86V86 | 4/20 | 0.47 |
| ▸ | DAPK3 | O43293 | 3/20 | 0.47 |
| ▸ | DYRK3 | O43781 | 3/20 | 0.47 |
| ▸ | HIPK2 | Q9H2X6 | 3/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.47 |
| ▸ | CSNK1G1 | Q9HCP0 | 3/20 | 0.47 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.47 |
| ▸ | GSK3B | P49841 | 3/20 | 0.47 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.45 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.45 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.45 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 4/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13002193 | 0.84 | PIK3CG (0.54) | MEN1KMT2APIM1GSK3BRAB9A | |
| SCHEMBL13766507 | 0.77 | CISD1 (0.44) | MEN1KMT2ANPC1RAB9APOLB | |
| SCHEMBL13002198 | 0.73 | HSPD1 (0.48) | PIM1TDP1 | |
| SCHEMBL13407209 | 0.73 | MYC (0.49) | MEN1KMT2APIM1PIM3PIM2 | |
| SCHEMBL13002189 | 0.73 | KMO (0.46) | MEN1KMT2ANPC1RAB9APOLB | |
| SCHEMBL13401717 | 0.72 | PIK3CG (0.73) | MEN1KMT2ANPC1PIM1GSK3B | |
| SCHEMBL13002190 | 0.71 | KMO (0.34) | MEN1KMT2ANPC1PIM1GSK3B | |
| SCHEMBL8290394 | 0.71 | MEN1 (0.52) | MEN1KMT2ANPC1RAB9APOLB | |
| SCHEMBL13002186 | 0.69 | MYC (0.53) | MEN1KMT2APIM1RAB9APOLB | |
| SCHEMBL12812662 | 0.69 | MYC (0.53) | MEN1KMT2ANPC1RAB9APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100099683-A1 | COMPOUNDS THAT INHIBIT HUMAN DNA LIGASES AND METHODS OF TREATING CANCER | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-04-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100099683-A1 | COMPOUNDS THAT INHIBIT HUMAN DNA LIGASES AND METHODS OF TREATING CANCER | LIG1, LIG4, LIG3 | MEN1 2792/4885KMT2A 1608/4885NPC1 3302/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.