Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CD44 | P16070 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | PTPRC | P08575 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | CASP7 | P55210 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25975073 | 0.82 | ALDH1A1 (0.65) | ALDH1A1HSD17B10L3MBTL1CYP3A4HPGD | |
| SCHEMBL4749661 | 0.82 | ALDH1A1 (0.46) | ALDH1A1HSD17B10L3MBTL1CD44CYP3A4 | |
| SCHEMBL7688458 | 0.80 | ALDH1A1 (0.62) | ALDH1A1HSD17B10L3MBTL1CD44CYP3A4 | |
| SCHEMBL169282 | 0.79 | ALDH1A1 (0.68) | ALDH1A1HSD17B10L3MBTL1CD44CYP3A4 | |
| SCHEMBL29564016 | 0.79 | ALDH1A1 (0.68) | ALDH1A1HSD17B10L3MBTL1CD44CYP3A4 | |
| SCHEMBL13729960 | 0.78 | PTGS2 (0.44) | ALDH1A1HSD17B10L3MBTL1CD44ADORA2A | |
| SCHEMBL6638917 | 0.78 | ABL1 (0.47) | ALDH1A1HSD17B10HPGDADORA2A | |
| SCHEMBL29414657 | 0.78 | CD44 (0.48) | ALDH1A1HSD17B10L3MBTL1CD44CYP3A4 | |
| SCHEMBL2602432 | 0.78 | CD44 (0.48) | ALDH1A1HSD17B10L3MBTL1CD44CYP3A4 | |
| SCHEMBL15365208 | 0.78 | KDR (0.46) | ALDH1A1HSD17B10L3MBTL1CD44CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100093748-A1 | SUBSTITUTED PIPERIDINES HAVING PROTEIN KINASE INHIBITING ACTIVITY | ASTEX THERAPEUTICS LIMITED (GB) | 2010-04-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100093748-A1 | SUBSTITUTED PIPERIDINES HAVING PROTEIN KINASE INHIBITING ACTIVITY | PRKAR2B, GRK3, PRKAR2A | ALDH1A1 4612/4885HSD17B10 3455/4885L3MBTL1 3190/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.