Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.52 |
| ▸ | NOS2 | P35228 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | GBA1 | P04062 | 1/20 | 0.34 |
| ▸ | NUDT1 | P36639 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL801826 | 0.82 | TRPM8 (0.42) | NOS3NOS2ALDH1A1TP53CYP3A4 | |
| SCHEMBL2625460 | 0.79 | ALDH1A1 (0.46) | NOS3NOS2ALDH1A1TP53CYP3A4 | |
| SCHEMBL20919369 | 0.78 | HRH4 (0.43) | NOS3NOS2NUDT1 | |
| SCHEMBL13485708 | 0.75 | NOS3 (0.57) | NOS3NOS2ALOX15ALDH1A1TP53 | |
| SCHEMBL13309905 | 0.74 | ALDH1A1 (0.39) | ALOX15ALDH1A1TP53CYP3A4TSHR | |
| SCHEMBL4915813 | 0.73 | NOS3 (0.60) | NOS3NOS2ALOX15ALDH1A1TP53 | |
| SCHEMBL17303780 | 0.72 | CCNT1 (0.40) | ALDH1A1TP53CYP3A4TSHRACHE | |
| SCHEMBL12411159 | 0.72 | NOS3 (0.48) | NOS3NOS2ALOX15ALDH1A1NUDT1 | |
| SCHEMBL12499637 | 0.71 | NOS3 (0.58) | NOS3NOS2ALOX15ALDH1A1CYP3A4 | |
| SCHEMBL10167712 | 0.71 | NOS3 (0.43) | NOS3NOS2ALDH1A1TP53CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015091584-A1 | THIAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND THEIR USE AS TYK2 KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2015-06-25 | — | — | WO | disclosed |
| US-7691853-B2 | Pyrazole compounds useful as protein kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-04-06 | — | — | US | disclosed |
| US-20090269379-A1 | Material Having Antibacterial and Antifungal Properties | CIBA CORP. | 2009-10-29 | — | — | US | disclosed |
| US-20070270444-A1 | Pyrazole compounds useful as protein kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED | 2007-11-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070270444-A1 | Pyrazole compounds useful as protein kinase inhibitors | GSK3B, CDK3, GSK3A | NOS3 715/4885NOS2 1597/4885ALOX15 3848/4885 |
| US-20090269379-A1 | Material Having Antibacterial and Antifungal Properties | POLR1C, NISCH, HSPH1 | NOS3 269/4885NOS2 530/4885ALOX15 2322/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.