Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 12/20 | 0.42 |
| ▸ | BRAF | P15056 | 10/20 | 0.42 |
| ▸ | AKT1 | P31749 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | GBA1 | P04062 | 2/20 | 0.38 |
| ▸ | AXL | P30530 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.37 |
| ▸ | MERTK | Q12866 | 1/20 | 0.37 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.37 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.37 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13439743 | 0.83 | RAF1 (0.42) | RAF1BRAFAKT1RAB9AALDH1A1 | |
| SCHEMBL11926323 | 0.79 | ALDH1A1 (0.43) | RAF1BRAFRAB9AALDH1A1MAPT | |
| SCHEMBL13439938 | 0.77 | MAPT (0.43) | RAF1BRAFAKT1RAB9AALDH1A1 | |
| SCHEMBL11926320 | 0.76 | GBA1 (0.45) | RAF1BRAFRAB9AALDH1A1MAPT | |
| SCHEMBL13439917 | 0.75 | DGAT1 (0.47) | RAF1BRAFRAB9AALDH1A1MAPT | |
| SCHEMBL11926333 | 0.73 | MAPT (0.47) | RAF1BRAFRAB9AALDH1A1MAPT | |
| SCHEMBL13439915 | 0.73 | MAPT (0.40) | RAF1BRAFRAB9AALDH1A1MAPT | |
| SCHEMBL13439960 | 0.72 | RAF1 (0.44) | RAF1BRAFAKT1RAB9AALDH1A1 | |
| SCHEMBL3112249 | 0.71 | KMO (0.49) | ALDH1A1MAPTSMN1; SMN2GBA1 | |
| SCHEMBL3112513 | 0.69 | DGAT1 (0.47) | RAB9AALDH1A1MAPTNPC1GBA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7696202-B2 | IL-12 modulatory compounds | SYNTA PHARMACEUTICALS CORP. (US) | 2010-04-13 | — | — | US | disclosed |