Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | NSD2 | O96028 | 1/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | DAO | P14920 | 1/20 | 0.32 |
| ▸ | CES1 | P23141 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8285727 | 0.82 | LMNA (0.36) | NOTUMALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL13440429 | 0.81 | LMNA (0.37) | LMNAELANEMEN1KMT2A | |
| SCHEMBL13440434 | 0.78 | ALDH1A1 (0.30) | ALDH1A1 | |
| SCHEMBL18726100 | 0.77 | HSD17B10 (0.44) | ALDH1A1LMNAELANEMEN1KMT2A | |
| SCHEMBL299421 | 0.71 | ALDH1A1 (0.50) | ALDH1A1NPC1RAB9ALMNAPKM | |
| SCHEMBL11384264 | 0.68 | ALDH1A1 (0.41) | ALDH1A1NPC1RAB9ASMN1; SMN2BCHE | |
| SCHEMBL4149675 | 0.68 | RET (0.46) | ALDH1A1NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL9662349 | 0.64 | ALDH1A1 (0.31) | ALDH1A1CYP2A6MEN1KMT2ATDP1 | |
| SCHEMBL18762903 | 0.64 | NOTUM (0.38) | NOTUMELANENSD2BCHEDAO | |
| SCHEMBL9179277 | 0.63 | RET (0.53) | ALDH1A1SMN1; SMN2LMNANSD2BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7674810-B2 | 1,1-dioxo-1H-1Λ6-benzo[d]isothiazol-3-yl)-4-hydroxy-1,5-dihydro-pyrrol-2-one inhibitors of HCV polymerase | ROCHE PALO ALTO LLC (US) | 2010-03-09 | — | — | US | disclosed |
| US-7674810-B2 | 1,1-dioxo-1H-1Λ6-benzo[d]isothiazol-3-yl)-4-hydroxy-1,5-dihydro-pyrrol-2-one inhibitors of HCV polymerase | ROCHE PALO ALTO LLC (US) | 2010-03-09 | — | — | US | disclosed |