Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13440446 | 0.81 | NOTUM (0.33) | LMNAELANEMEN1KMT2A | |
| SCHEMBL18726100 | 0.77 | HSD17B10 (0.44) | LMNAELANEPOLBCA1CA2 | |
| SCHEMBL13440434 | 0.75 | ALDH1A1 (0.30) | — | |
| SCHEMBL8285727 | 0.72 | LMNA (0.36) | LMNAELANEPOLBGAAKMT2A | |
| SCHEMBL18726160 | 0.71 | — | — | |
| SCHEMBL13440430 | 0.71 | PKM (0.60) | LMNASLC40A1ELANEGAAHSD17B10 | |
| SCHEMBL10908088 | 0.70 | LMNA (0.41) | LMNAELANEPOLBCA1CA2 | |
| SCHEMBL1866201 | 0.69 | SLC40A1 (0.41) | SLC40A1POLBCA1CA2MEN1 | |
| SCHEMBL299421 | 0.68 | ALDH1A1 (0.50) | LMNAPOLBGAAHSD17B10HTT | |
| SCHEMBL11384264 | 0.66 | ALDH1A1 (0.41) | GAAHSD17B10HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7674810-B2 | 1,1-dioxo-1H-1Λ6-benzo[d]isothiazol-3-yl)-4-hydroxy-1,5-dihydro-pyrrol-2-one inhibitors of HCV polymerase | ROCHE PALO ALTO LLC (US) | 2010-03-09 | — | — | US | disclosed |
| US-7674810-B2 | 1,1-dioxo-1H-1Λ6-benzo[d]isothiazol-3-yl)-4-hydroxy-1,5-dihydro-pyrrol-2-one inhibitors of HCV polymerase | ROCHE PALO ALTO LLC (US) | 2010-03-09 | — | — | US | disclosed |