Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | GRK5 | P34947 | 1/20 | 0.46 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.46 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.46 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.38 |
| ▸ | CA12 | O43570 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | CA9 | Q16790 | 2/20 | 0.36 |
| ▸ | CA4 | P22748 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8285729 | 0.81 | RET (0.43) | RETGRK5TYRO3DYRK1BCXCR2 | |
| SCHEMBL2449016 | 0.81 | CXCR2 (0.38) | RETGRK5TYRO3DYRK1BCXCR2 | |
| SCHEMBL10911011 | 0.81 | CA12 (0.33) | RETGRK5TYRO3DYRK1BCXCR2 | |
| SCHEMBL2564355 | 0.81 | RET (0.43) | RETGRK5TYRO3DYRK1BCXCR2 | |
| SCHEMBL13903578 | 0.77 | RET (0.40) | RETGRK5TYRO3DYRK1BCXCR2 | |
| SCHEMBL4129036 | 0.77 | HSD17B10 (0.48) | CXCR2CA1CA2CA9CA7 | |
| SCHEMBL13903576 | 0.77 | TSHR (0.44) | RETGRK5TYRO3DYRK1BALDH1A1 | |
| SCHEMBL10167427 | 0.74 | LMNA (0.39) | RETGRK5TYRO3DYRK1BCXCR2 | |
| SCHEMBL13903591 | 0.74 | RET (0.38) | RETGRK5TYRO3DYRK1BCXCR2 | |
| SCHEMBL13903622 | 0.74 | RET (0.38) | RETGRK5TYRO3DYRK1BCXCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090069317-A1 | Insecticidal Methods Using 3-Amino-1,2-Benzisothiazole Derivatives | BASF SE (DE) | 2009-03-12 | — | — | US | disclosed |
| US-4590192-A | ANTIULCER AGENTS | BEECHAM GROUP P.L.C. (GB) | 1986-05-20 | — | — | US | disclosed |
| EP-0033984-B1 | NEW SULPHONYL COMPOUNDS, METHOD OF PREPARING THE NEW COMPOUNDS, AS WELL AS APHICIDAL COMPOSITIONS ON THE BASIS OF THE NEW COMPOUNDS | DUPHAR INTERNATIONAL RESEARCH B.V (NL) | 1984-06-06 | — | — | EP | disclosed |
| EP-0105732-A2 | Histamine H2 receptor antagonists of the benzisothiazole amino and benzthiadiazine amino series | BEECHAM GROUP PLC (GB) | 1984-04-18 | — | — | EP | disclosed |
| US-4379157-A | Sulphonyl compounds, method of preparing the new compounds, as well as aphicidal compositions on the basis of the new compounds | DUPHAR INTERNATIONAL RESEARCH B.V. (NL) | 1983-04-05 | — | — | US | disclosed |
| EP-0033984-A1 | New sulphonyl compounds, method of preparing the new compounds, as well as aphicidal compositions on the basis of the new compounds | DUPHAR INTERNATIONAL RESEARCH B.V (NL) | 1981-08-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090069317-A1 | Insecticidal Methods Using 3-Amino-1,2-Benzisothiazole Derivatives | AAAS, API5, ATL3 | RET 4018/4885GRK5 1421/4885TYRO3 1294/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.