Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.36 |
| ▸ | P2RY6 | Q15077 | 2/20 | 0.34 |
| ▸ | P2RY14 | Q15391 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.34 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.34 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.34 |
| ▸ | NT5E | P21589 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | PRKCA | P17252 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20051999 | 0.89 | POLB (0.43) | POLBHSD17B10MAPTABL1RIN1 | |
| SCHEMBL14867647 | 0.86 | POLB (0.41) | POLBHSD17B10MAPTABL1RIN1 | |
| SCHEMBL13443479 | 0.85 | MAPT (0.45) | POLBHSD17B10MAPTL3MBTL1TSHR | |
| SCHEMBL13443492 | 0.80 | POLB (0.33) | POLBHSD17B10MAPTL3MBTL1 | |
| SCHEMBL13443477 | 0.77 | POLB (0.79) | POLBHSD17B10MAPTL3MBTL1ALDH1A1 | |
| SCHEMBL20052002 | 0.75 | POLB (0.32) | POLBHSD17B10MAPTADRB2ADRB1 | |
| SCHEMBL14867649 | 0.74 | POLB (0.31) | POLBHSD17B10 | |
| SCHEMBL20052001 | 0.72 | MAPT (0.44) | HSD17B10MAPTABL1L3MBTL1TSHR | |
| SCHEMBL18480144 | 0.72 | MAPT (0.37) | MAPTMAPK8 | |
| SCHEMBL23710595 | 0.70 | POLB (0.85) | POLBHSD17B10ALDH1A1ADRB2ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8314227-B2 | Hydroxymethyl substituted RNA oligonucleotides and RNA complexes | MARINA BIOTECH, INC. (US) | 2012-11-20 | — | — | US | disclosed |
| US-20100056768-A1 | HYDROXYMETHYL SUBSTITUTED RNA OLIGONUCLEOTIDES AND RNA COMPLEXES | MDRNA, INC. (US) | 2010-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100056768-A1 | HYDROXYMETHYL SUBSTITUTED RNA OLIGONUCLEOTIDES AND RNA COMPLEXES | NSUN2, METTL16, NSUN3 | POLB 295/4885HSD17B10 1606/4885MAPT 3799/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.