Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCNN1A | P37088 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.39 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CASR | P41180 | 1/20 | 0.37 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1344939 | 0.89 | SLC1A3 (0.45) | LMNASCN5ASCN2ADDAH1SMN1; SMN2 | |
| SCHEMBL1344948 | 0.82 | POLB (0.45) | ALDH1A1KMT2AMAPTSCN5ASCN2A | |
| SCHEMBL1345511 | 0.82 | KDM4E (0.39) | ALDH1A1CYP2C19KMT2AMAPTGAA | |
| SCHEMBL1345053 | 0.81 | FDFT1 (0.42) | LMNAATM | |
| SCHEMBL1345111 | 0.81 | CTSD (0.39) | DDAH1 | |
| SCHEMBL1342933 | 0.81 | ADRB2 (0.42) | ALDH1A1KMT2AHTTGAASMN1; SMN2 | |
| SCHEMBL1345420 | 0.80 | DDAH1 (0.47) | ALDH1A1CYP2C19KMT2AMAPTGAA | |
| SCHEMBL1343488 | 0.79 | DDAH1 (0.43) | ALDH1A1CYP2C19MAPTSCN5ASCN2A | |
| SCHEMBL1345238 | 0.78 | DDAH1 (0.44) | DDAH1 | |
| SCHEMBL1343296 | 0.78 | DDAH1 (0.43) | ALDH1A1MAPTGAADDAH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8063104-B2 | Guanidine derivatives as inhibitors of DDAH | UCL BUSINESS PLC (GB) | 2011-11-22 | — | — | US | disclosed |