Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 1/20 | 0.41 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | TGM2 | P21980 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1345511 | 0.88 | KDM4E (0.39) | MRGPRX4MAOBCYP1A2CYP2D6CYP2C9 | |
| SCHEMBL1344948 | 0.87 | POLB (0.45) | CYP2D6MMP12ALDH1A1GAAGPBAR1 | |
| SCHEMBL1344939 | 0.85 | SLC1A3 (0.45) | L3MBTL1 | |
| SCHEMBL1345111 | 0.85 | CTSD (0.39) | EPHX1 | |
| SCHEMBL1345053 | 0.83 | FDFT1 (0.42) | ADRA2AMMP1MMP12L3MBTL1 | |
| SCHEMBL1342933 | 0.76 | ADRB2 (0.42) | ADRB1ALDH1A1GAA | |
| SCHEMBL1345420 | 0.75 | DDAH1 (0.47) | ALDH1A1GAA | |
| SCHEMBL1343488 | 0.74 | DDAH1 (0.43) | CYP2D6CYP2C9ALDH1A1GAA | |
| SCHEMBL1343518 | 0.73 | CA12 (0.46) | L3MBTL1 | |
| SCHEMBL1343296 | 0.73 | DDAH1 (0.43) | ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8063104-B2 | Guanidine derivatives as inhibitors of DDAH | UCL BUSINESS PLC (GB) | 2011-11-22 | — | — | US | disclosed |