Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 7/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 1.00 |
| ▸ | ALOX12 | P18054 | 2/20 | 1.00 |
| ▸ | MEN1 | O00255 | 7/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.74 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.74 |
| ▸ | MAPT | P10636 | 8/20 | 0.58 |
| ▸ | HTT | P42858 | 6/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | IDH1 | O75874 | 6/20 | 0.56 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13453450 | 0.85 | SMN1; SMN2 (1.00) | LMNAALDH1A1SMN1; SMN2ALOX12MEN1 | |
| SCHEMBL13453459 | 0.78 | SMN1; SMN2 (0.67) | LMNAALDH1A1SMN1; SMN2ALOX12MEN1 | |
| SCHEMBL13453467 | 0.74 | ALDH1A1 (0.70) | LMNAALDH1A1SMN1; SMN2ALOX12MEN1 | |
| SCHEMBL14096534 | 0.73 | RAB9A (0.62) | LMNAALDH1A1SMN1; SMN2ALOX12MEN1 | |
| SCHEMBL27181401 | 0.73 | KMT2A (0.71) | LMNAALDH1A1SMN1; SMN2ALOX12MEN1 | |
| SCHEMBL13454623 | 0.73 | ALDH1A1 (0.70) | LMNAALDH1A1SMN1; SMN2ALOX12MEN1 | |
| SCHEMBL13454754 | 0.73 | ALDH1A1 (0.66) | LMNAALDH1A1SMN1; SMN2ALOX12MEN1 | |
| SCHEMBL5457993 | 0.73 | KDM4E (0.65) | LMNAALDH1A1SMN1; SMN2ALOX12MEN1 | |
| SCHEMBL15702455 | 0.72 | IDH1 (1.00) | LMNASMN1; SMN2MEN1KMT2ANPSR1 | |
| SCHEMBL13453429 | 0.72 | MEN1 (0.58) | LMNAALDH1A1SMN1; SMN2ALOX12MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9126938-B2 | Phosphatidylcholine transfer protein inhibitors | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2015-09-08 | — | — | US | disclosed |
| US-9126938-B2 | Phosphatidylcholine transfer protein inhibitors | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2015-09-08 | — | — | US | disclosed |
| US-20120264756-A1 | Phosphatidylcholine Transfer Protein Inhibitors | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2012-10-18 | — | — | US | disclosed |
| US-20120264756-A1 | Phosphatidylcholine Transfer Protein Inhibitors | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2012-10-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120264756-A1 | Phosphatidylcholine Transfer Protein Inhibitors | PCTP, LCAT, CETP | LMNA 2945/4885ALDH1A1 4289/4885SMN1; SMN2 4659/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.