Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | TP53 | P04637 | 2/20 | 0.58 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.57 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | BLM | P54132 | 1/20 | 0.54 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.54 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | LDLR | P01130 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29373842 | 0.90 | MAPT (0.65) | MAPTSMN1; SMN2TP53MEN1HTT | |
| SCHEMBL30445827 | 0.90 | MAPT (0.65) | MAPTSMN1; SMN2TP53MEN1HTT | |
| SCHEMBL10063837 | 0.90 | MAPT (0.65) | MAPTSMN1; SMN2TP53MEN1HTT | |
| SCHEMBL13480571 | 0.83 | MAPT (0.52) | MAPTSMN1; SMN2TP53MEN1POLB | |
| SCHEMBL13679715 | 0.82 | MAPT (0.69) | MAPTSMN1; SMN2TP53ADORA2AMEN1 | |
| SCHEMBL13679540 | 0.79 | RAF1 (0.59) | MAPTHPSERECQLADORA2AMEN1 | |
| SCHEMBL13679573 | 0.79 | ADORA2A (0.57) | MAPTHPSERECQLADORA2AMEN1 | |
| SCHEMBL5822958 | 0.79 | MAPT (0.72) | MAPTSMN1; SMN2TP53MEN1HTT | |
| SCHEMBL14615299 | 0.78 | MAPT (0.66) | MAPTTP53HPSEMEN1HTT | |
| SCHEMBL13679559 | 0.78 | MEN1 (0.78) | MAPTSMN1; SMN2TP53HPSEADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100069386-A1 | Modulators of Hedgehog Signaling Pathways, Compositions and Uses Related Thereto | THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE | 2010-03-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100069386-A1 | Modulators of Hedgehog Signaling Pathways, Compositions and Uses Related Thereto | SHH, SMO, GLI1 | MAPT 4506/4885SMN1; SMN2 4522/4885TP53 571/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.